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MINK1 [cytosol]
Stable Identifier
R-HSA-2532788
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Misshapen-like kinase 1, MINK, GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, MEKKK 6, B55, MAP4K6, YSK2, ZC3
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Expression of MINK1/TNIK is positively regulated by ROS (Homo sapiens)
MINK1/TNIK [cytosol] (Homo sapiens)
MINK1 [cytosol] (Homo sapiens)
ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)
MINK1/TNIK [cytosol] (Homo sapiens)
MINK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N4C8 MINK1
Gene Names
MINK1, B55, MAP4K6, MINK, YSK2, ZC3
Chain
chain:1-1332
Reference Genes
BioGPS Gene:50488 MINK1
COSMIC (genes):MINK1 MINK1
CTD Gene:50488 MINK1
dbSNP Gene:50488 MINK1
ENSEMBL:ENSG00000141503 MINK1
ENSEMBL_homo_sapiens_GENE:ENSG00000141503.17 MINK1
HGNC:17565 MINK1
KEGG Gene (Homo sapiens):50488 MINK1
Monarch:50488 MINK1
NCBI Gene:50488 MINK1
OMIM:609426 MINK1
UCSC:Q8N4C8 MINK1
Reference Transcript
RefSeq:NM_001321236.1 MINK1
RefSeq:NM_153827.4 MINK1
RefSeq:NM_001024937.3 MINK1
RefSeq:NM_015716.4 MINK1
RefSeq:NM_170663.4 MINK1
Other Identifiers
11720873_a_at
11730084_x_at
16829922
209241_PM_x_at
209241_x_at
214246_3p_x_at
214246_PM_x_at
214246_x_at
214625_PM_s_at
214625_s_at
215909_PM_x_at
215909_x_at
3707259
3707260
3707261
3707273
3707274
3707275
3707276
3707277
3707278
3707279
3707281
3707282
3707283
3707284
3707287
3707288
3707289
3707290
3707291
3707292
3707293
3707295
3707298
3707302
3707303
3707304
3707306
3707307
3707309
3707311
3707313
3707315
3707316
3707319
3707320
3707321
3707322
39833_at
50488
8003991
A_14_P100646
A_14_P104880
A_14_P129227
A_23_P164307
A_23_P164313
GE53980
GE79696
GO:0000165
GO:0000166
GO:0001952
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005737
GO:0005794
GO:0005829
GO:0006468
GO:0007010
GO:0007155
GO:0007254
GO:0007268
GO:0007420
GO:0014069
GO:0016301
GO:0016310
GO:0016740
GO:0022407
GO:0023052
GO:0030036
GO:0030154
GO:0030334
GO:0030424
GO:0030425
GO:0036211
GO:0042995
GO:0043226
GO:0043408
GO:0045202
GO:0046330
GO:0046777
GO:0048812
GO:0048813
GO:0048856
GO:0048870
GO:0055085
GO:0070062
GO:0106310
GO:0140096
GO:1900745
GO:2000311
HMNXSV003042358
Hs.112028.1.S2_3p_x_at
Hs.112028.2.S1_3p_x_at
ILMN_1717101
ILMN_2306692
PH_hs_0006138
TC17000054.hg
g7637420_3p_x_at
Participates
as a member of
MINK1/TNIK [cytosol] (Homo sapiens)
Inferred To
Homologues of MINK1 [cytosol]
(Caenorhabditis elegans)
MINK1 [cytosol]
(Bos taurus)
MINK1 [cytosol]
(Caenorhabditis elegans)
MINK1 [cytosol]
(Drosophila melanogaster)
MINK1 [cytosol]
(Mus musculus)
MINK1 [cytosol]
(Rattus norvegicus)
MINK1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_733763.1
,
NP_001020108.1
,
NP_056531.1
,
NP_722549.2
,
NP_001308165.1
ZINC - World Drugs
MINK1_HUMAN
Guide to Pharmacology - Targets
2103
OpenTargets
ENSG00000141503
ZINC - FDA approved
MINK1_HUMAN
ZINC - Substances
MINK1_HUMAN
ZINC - Biogenic
MINK1_HUMAN
ZINC target
Q8N4C8
PRO
Q8N4C8
ZINC - Investigational
MINK1_HUMAN
GeneCards
Q8N4C8
HPA
ENSG00000141503-MINK1
Ensembl
ENSP00000269296
,
ENST00000355280
,
ENSP00000347427
,
ENSP00000406487
,
ENSG00000141503
,
ENST00000453408
,
ENST00000347992
Pharos - Targets
Q8N4C8
ZINC - Predictions - Purchasable
MINK1_HUMAN
Orphanet
24701
HMDB Protein
HMDBP08758
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00613 HSF1
11
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
HSF1 [cytosol]
(R-HSA-3371452)
0.544
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.471
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
3
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