METAP1/2 demethylates GNAT1

Stable Identifier
Reaction [transition]
Homo sapiens
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All eukaryotic proteins synthesized in the cytosol are initiated by methionine (Met). For the maturation of many proteins, the removal of N-terminal Met is essential and is mediated by methionine-aminopeptidases (METAPs). In human, there are two forms, METAP1 and 2 (Arfin et al. 1995). These enzymes utilise 2 cobalt ions (Co2+) as cofactors (Addlagatta et al. 2005, Hu et al. 2006, Marino et al. 2007).
Literature References
PubMed ID Title Journal Year
16274222 Structural basis for the functional differences between type I and type II human methionine aminopeptidases

Liu, JO, Hu, X, Addlagatta, A, Matthews, BW

Biochemistry 2005
7644482 Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes

Matthews, BW, Kendall, RL, Hall, L, Arfin, SM, Stewart, AE, Weaver, LH, Bradshaw, RA

Proc. Natl. Acad. Sci. U.S.A. 1995
17636946 Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore

Mattern, M, Tew, DG, Schulz, C, Veber, DF, Smith, WW, Thompson, SK, Fisher, PW, Ma, C, Janson, CA, Kirkpatrick, RB, Meek, TD, Marino, JP, Hofmann, GA, Yang, G, Tomazek, TA, Yamamoto, Y, Xiong, WC, Ryan, MD, Johnson, RK, Yamashita, K

J. Med. Chem. 2007
17114291 Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression

Lu, J, Liu, JO, Hu, X, Addlagatta, A, Matthews, BW

Proc. Natl. Acad. Sci. U.S.A. 2006
Catalyst Activity

aminopeptidase activity of METAP1/2 [cytosol]

Orthologous Events
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