Reactome | METAP1 [cytosol]

METAP1 [cytosol]

Stable Identifier

R-HSA-2534097

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Methionine aminopeptidase 1, AMPM1_HUMAN

Locations in the PathwayBrowser

Expand all

Sensory Perception (Homo sapiens)

- Visual phototransduction (Homo sapiens)
  - The phototransduction cascade (Homo sapiens)
    - Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
      - METAP1/2 demethylates GNAT1 (Homo sapiens)
        
        METAP1/2 [cytosol] (Homo sapiens)
        
        METAP1:2Co2+ [cytosol] (Homo sapiens)
        
        METAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53582 METAP1

Gene Names

METAP1, KIAA0094

Chain

initiator methionine:, chain:2-386

Reference Genes

BioGPS Gene:23173 METAP1

COSMIC (genes):METAP1 METAP1

CTD Gene:23173 METAP1

dbSNP Gene:23173 METAP1

ENSEMBL:ENSG00000164024 METAP1

HGNC:15789 METAP1

KEGG:hsa:23173 METAP1

Monarch:23173 METAP1

NCBI Gene:23173 METAP1

OMIM:610151 METAP1

UCSC:P53582 METAP1

Reference Transcript

RefSeq:NM_015143.3 METAP1

Other Identifiers

11720055_at

11720056_a_at

16969131

212673_PM_at

212673_at

23173

2737072

2737073

2737074

2737075

2737077

2737078

2737079

2737082

2737084

2737086

2737087

2737088

2737090

2737091

2737092

2737094

2737095

2737096

2737097

2737098

2737099

2737101

2737103

2737104

2737105

2737106

2737107

2737117

37619_at

8096556

A_14_P137160

A_14_P200127

A_23_P155907

A_24_P226076

D42084_at

GE57208

GO:0003824

GO:0004177

GO:0004239

GO:0005515

GO:0005737

GO:0005829

GO:0005840

GO:0006417

GO:0006508

GO:0007155

GO:0008235

GO:0008270

GO:0016787

GO:0018206

GO:0022626

GO:0031365

GO:0043226

GO:0046872

GO:0051604

GO:0070006

GO:0070527

GO:0140096

HMNXSV003004990

Hs.82007.0.S1_3p_at

ILMN_1785795

PH_hs_0004684

Participates

as a component of

METAP1:2Co2+ [cytosol] (Homo sapiens)

Inferred To

metap1 [cytosol] (Danio rerio)

metap1 [cytosol] (Dictyostelium discoideum)

metap1 [cytosol] (Xenopus tropicalis)

fma1 [cytosol] (Schizosaccharomyces pombe)

METAP1 [cytosol] (Bos taurus)

METAP1 [cytosol] (Canis familiaris)

METAP1 [cytosol] (Sus scrofa)

MAP1 [cytosol] (Saccharomyces cerevisiae)

Metap1 [cytosol] (Mus musculus)

Metap1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_055958.2

ZINC - World Drugs

MAP11_HUMAN

Guide to Pharmacology - Targets

1572

OpenTargets

ENSG00000164024

ENSEMBL

ENST00000296411, ENSG00000164024, ENSP00000296411

ZINC - Substances

MAP11_HUMAN

ZINC - Biogenic

MAP11_HUMAN

ZINC target

P53582

PRO

P53582

GlyGen

P53582

PDB

4U6C, 4IKS, 2B3H, 4IKR, 8P2K, 4U6W, 5YR4, 4U76, 4U6E, 4U71, 5YR5, 4U70, 5YR7, 5YR6, 4U69, 9FQ0, 5YKP, 2GZ5, 2NQ7, 2NQ6, 4IU6, 4FLI, 4HXX, 6LZB, 9F1C, 4IKU, 4U75, 4U1B, 4FLK, 2B3L, 2B3K, 4FLL, 6LZC, 2G6P, 4IKT, 9F1D, 4U73, 4U6J, 4U6Z, 4FLJ

ZINC - Metabolites

MAP11_HUMAN

IntEnz

3.4.11.18

HPA

ENSG00000164024-METAP1

GeneCards

METAP1

Pharos - Targets

P53582

ZINC - Predictions - Purchasable

MAP11_HUMAN

HMDB Protein

HMDBP08233

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.601	4
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
UniProt:P01160 NPPA	5	NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2