Reactome | ID1 [nucleoplasm]

ID1 [nucleoplasm]

Stable Identifier

R-HSA-2534101

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA-binding protein inhibitor ID-1, Class B basic helix-loop-helix protein 24, BHLHB24, Inhibitor of DNA binding 1

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        ID1 and ID3 gene expression (Homo sapiens)
        
        ID1, ID3 [nucleoplasm] (Homo sapiens)
        
        ID1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P41134 ID1

Gene Names

ID1, BHLHB24, ID

Chain

chain:1-155

Reference Genes

BioGPS Gene:3397 ID1

COSMIC (genes):ID1 ID1

CTD Gene:3397 ID1

dbSNP Gene:3397 ID1

ENSEMBL:ENSG00000125968 ID1

HGNC:5360 ID1

KEGG:hsa:3397 ID1

Monarch:3397 ID1

NCBI Gene:3397 ID1

OMIM:600349 ID1

UCSC:P41134 ID1

Reference Transcript

Other Identifiers

11716195_a_at

11716196_x_at

11753661_a_at

16912362

208937_PM_s_at

208937_s_at

3397

36617_at

36618_g_at

36619_r_at

3881392

3881393

3881394

3881395

3881396

3881397

3881398

3881399

3881400

3881401

8061564

ADDON002895.hg

A_14_P121564

A_23_P252306

GE58816

GE81126

GE86461

GO:0000122

GO:0001525

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006355

GO:0007179

GO:0010621

GO:0030154

GO:0032922

GO:0043226

GO:0043433

GO:0043534

GO:0045892

GO:0046983

GO:0048511

GO:0048514

GO:0048870

GO:0098772

GO:0120163

GO:0140416

HMNXSV003020610

ILMN_1664861

ILMN_1665832

PH_hs_0024850

S78825_at

TC20000194.hg

g464181_3p_a_at

Participates

as an output of

TBX3-dependent ID1 gene expression (Homo sapiens)

as a member of

ID1, ID3 [nucleoplasm] (Homo sapiens)

as an input of

ID1 sequesters ETS2 (Homo sapiens)

as a component of

p-T72-ETS2:ID1 [nucleoplasm] (Homo sapiens)

Inferred To

emc [nucleoplasm] (Drosophila melanogaster)

id1 [nucleoplasm] (Danio rerio)

Id1 [nucleoplasm] (Gallus gallus)

Id1 [nucleoplasm] (Mus musculus)

Id1 [nucleoplasm] (Rattus norvegicus)

ID1 [nucleoplasm] (Bos taurus)

ID1 [nucleoplasm] (Canis familiaris)

ID1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_851998.1, NP_002156.2

ENSEMBL

ENSP00000365280, ENSP00000365273, ENST00000376105, ENST00000376112

OpenTargets

ENSG00000125968

HPA

ENSG00000125968-ID1

ZINC - Substances

ID1_HUMAN

ZINC target

P41134

PRO

P41134

Pharos - Targets

P41134

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.659	4
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.602	6
UniProt:P15173 MYOG	1	MYOG [nucleoplasm] (R-HSA-445160)	0.601	4
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P15923-3 TCF3			0.556	3
UniProt:P13349 MYF5	1	MYF5 [nucleoplasm] (R-HSA-445158)	0.556	5
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q99081-3 TCF12			0.556	3
UniProt:P15884-3 TCF4			0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:Q9NQ33 ASCL3			0.556	3
UniProt:A6NI15 MSGN1	1	MSGN1 [nucleoplasm] (R-HSA-9793376)	0.556	5
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.547	3
UniProt:O14936 CASK	1	CASK [cytosol] (R-HSA-373631)	0.508	3
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.488	2
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.463	2

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