Hv1 Mediated H+ Permeability

Stable Identifier
R-HSA-2534378
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Intracellular alkalinization is essential for the initiation of motility, capacitation, hyperactivation, and the acrosome reaction. Hv1 mediates the voltage-dependent proton permeability of excitable membranes. Hv1 is abundantly expressed in human sperm cells within the principal piece of the sperm flagellum, making it ideally positioned to activate pH-dependent proteins of the axoneme and thus to control sperm motility.
Literature References
PubMed ID Title Journal Year
20144758 Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel

Botchkina, IL, Lishko, PV, Kirichok, Y, Fedorenko, A

Cell 2010
Participants
Participates
Catalyst Activity

voltage-gated cation channel activity of HV1 Channel [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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