Deacetylation of cleaved cohesin

Stable Identifier
Reaction [transition]
Homo sapiens
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Histone deacetylase HDAC8 deacetylates SMC3 cohesin subunit. SMC3 deacetylation promotes dissociation of cleaved RAD21 fragments from other cohesin proteins and their replacement with intact RAD21, thereby allowing restoration of the cohesin complex (Deardorff et al. 2012). HDAC8 mutations, as well as mutations in NIPBL, SMC1A and SMC3, can cause Cornelia de Lang syndrome (Deardorff et al. 2012).

Literature References
PubMed ID Title Journal Year
22885700 HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

Shirahige, K, Kiyono, T, Magnaghi-Jaulin, L, Clark, D, Katou, Y, Krantz, ID, Kaiser, FJ, Takagaki, K, Ernst, S, Nozaki, N, Siu, VM, Prigent, C, Christianson, DW, De Baere, E, Decroos, C, Francey, LJ, Di Donato, N, Bando, M, Saitoh, K, Kaur, M, Hirashima, K, Itoh, T, Suzuki, Y, Nakato, R, Mortier, GR, Seimiya, H, Wilde, JJ, Gillessen-Kaesbach, G, Jackson, LG, Watrin, E, Gyftodimou, Y, Willems, PJ, Lombardi, PM, Petersen, MB, Deardorff, MA, Ishikawa, Y, Minamino, M, Jaulin, C, Cole, KE, Hirota, T, Komata, M, Hullings, M

Nature 2012
Catalyst Activity

histone deacetylase activity of HDAC8 [cytosol]

Orthologous Events
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