TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane]

Stable Identifier
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
MAL:PI(4,5)P2:activated TLR2/4
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
11544529 Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Jefferies, CA, O'Neill, LA, Mansell, AS, Bird, TA, Brint, E, Smith, DE, Gray, P, Sims, JE, Palsson-McDermott, EM, Bowie, AG, Harte, MT, Fitzgerald, KA, McMurray, D, Dunne, A, Brady, G

Nature 2001
17726518 A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

Westoll, JF, Brooks, HJ, Wong, J, O'Neill, LA, Núñez Miguel, R, Gay, NJ, Monie, TP, Bryant, CE

PLoS One 2007
21873236 Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

Martin, JL, Dimaio, F, Sweet, MJ, Baker, D, Valkov, E, Verstak, B, Kobe, B, Mansell, A, Gay, NJ, Stamp, A, Roversi, P, Kellie, S

Proc. Natl. Acad. Sci. U.S.A. 2011
16439361 MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

Brikos, C, O'Neill, LA, Gray, P, Doyle, SL, Jefferies, CA, Dunne, A

J Biol Chem 2006
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