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SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
Stable Identifier
R-HSA-2559578
Type
Complex
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
SARM:TICAM1:activated TLR4, SARM:TRIF:TRAM:TLR4:LY96:LPS:CD14
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
IKK complex recruitment mediated by RIP1 (Homo sapiens)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16964262
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
Schröder, M
,
Stack, J
,
Moynagh, PN
,
Carty, M
,
Bowie, AG
,
Goodbody, R
Nat. Immunol.
2006
Participants
components
SARM-1 [cytosol]
(Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(Homo sapiens)
Participates
as an output of
SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)
This entity regulates
Negatively
TRAF3 binds TICAM1:activated TLR4 complex
(Homo sapiens)
TRIF:activated TLR3/TLR4 complex recruits RIP1
(Homo sapiens)
Activated TLR4:TICAM1 recruits TRAF6
(Homo sapiens)
Inferred To
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(Bos taurus)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(Canis familiaris)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(Mus musculus)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(Rattus norvegicus)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(Sus scrofa)
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