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PPM1D [nucleoplasm]
Stable Identifier
R-HSA-2562518
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WIP1, Protein phosphatase 1D
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
PPM1D dephosphorylates RUNX2 (Homo sapiens)
PPM1D [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15297 PPM1D
Gene Names
PPM1D, WIP1
Chain
chain:1-605
Reference Genes
BioGPS Gene:8493 PPM1D
COSMIC (genes):PPM1D PPM1D
CTD Gene:8493 PPM1D
dbSNP Gene:8493 PPM1D
ENSEMBL:ENSG00000170836 PPM1D
HGNC:9277 PPM1D
KEGG:hsa:8493 PPM1D
Monarch:8493 PPM1D
NCBI Gene:8493 PPM1D
OMIM:605100 PPM1D
UCSC:O15297 PPM1D
Reference Transcript
RefSeq:NM_003620.3 PPM1D
Other Identifiers
11739369_s_at
11739370_a_at
11751018_a_at
11752090_a_at
16836684
204566_PM_at
204566_at
230330_PM_at
230330_at
37107_at
3729538
3729539
3729540
3729541
3729542
3729543
3729546
3729547
3729549
3729550
3729551
3729552
3729553
3729554
3729555
3729556
3729557
3729558
3729559
3729560
51609_r_at
8008922
8493
A_14_P101951
A_14_P126509
A_32_P150030
A_33_P3302696
GE79845
GO:0000086
GO:0003824
GO:0004674
GO:0004721
GO:0004722
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006325
GO:0006346
GO:0006355
GO:0006470
GO:0008285
GO:0009267
GO:0009314
GO:0009617
GO:0016740
GO:0016787
GO:0017018
GO:0030330
GO:0035970
GO:0043169
GO:0043226
GO:0045814
GO:0046872
GO:0051019
GO:0060260
GO:0140096
HMNXSV003007394
Hs.286073.0.A1_3p_at
ILMN_1670875
PH_hs_0023484
TC17000739.hg
TC17002305.hg
g4505996_3p_at
Inferred To
Pp2C1 [nucleoplasm]
(Drosophila melanogaster)
ppm-1.d [nucleoplasm]
(Caenorhabditis elegans)
PPM1D [nucleoplasm]
(Bos taurus)
PPM1D [nucleoplasm]
(Canis familiaris)
PPM1D [nucleoplasm]
(Gallus gallus)
PPM1D [nucleoplasm]
(Mus musculus)
PPM1D [nucleoplasm]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
3134
ENSEMBL
ENSP00000306682
,
ENSP00000376720
,
ENST00000305921
,
ENST00000392995
OpenTargets
ENSG00000170836
HPA
ENSG00000170836-PPM1D
ZINC - Substances
PPM1D_HUMAN
ZINC target
O15297
PRO
O15297
Pharos - Targets
O15297
GlyGen
O15297
Orphanet
PPM1D
HMDB Protein
HMDBP08794
PDB
8T2J
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13950 RUNX2
0.602
4
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.544
3
UniProt:Q00987 MDM2
11
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
MDM2 [cytosol]
(R-HSA-198644)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
MDM2 [plasma membrane]
(R-HSA-416843)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
0.544
4
UniProt:Q14974 KPNB1
5
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
0.527
2
UniProt:P52292 KPNA2
2
KPNA2 [cytosol]
(R-HSA-205976)
KPNA2 [nucleoplasm]
(R-HSA-206045)
0.527
2
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