Phosphorylated OPTN translocates to the nucleus

Stable Identifier
R-HSA-2562594
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Phosphorylated OPTN translocates to the nucleus
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Phosphorylation of OPTN (optineurin) on serine S177 by PLK1 promotes translocation of OPTN to the nucleus (Kachaner et al. 2012).
Literature References
PubMed ID Title Journal Year
22365832 Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

Kachaner, D, Filipe, J, Laplantine, E, Bauch, A, Bennett, KL, Superti-Furga, G, Israel, A, Weil, R

Mol. Cell 2012
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Orthologous Events
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Phosphorylated OPTN translocates to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-01-29)
Reviewed
Weil, R  (2013-02-07)
Created
Orlic-Milacic, M  (2012-11-06)
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