AJUBA facilitates AURKA autophosphorylation

Stable Identifier
R-HSA-2574840
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AJUBA facilitates AURKA autophosphorylation
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AURKA (Aurora A kinase) activation through autophosphorylation of threonine T288 is facilitated by AJUBA binding. AJUBA is also phosphorylated by AURKA on an unidentified serine or threonine residue (Hirota et al. 2003).

Literature References
PubMed ID Title Journal Year
13678582 Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

Hirota, T, Hatakeyama, K, Nitta, M, Sasayama, T, Saya, H, Kunitoku, N, Zhang, D, Marumoto, T

Cell 2003
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of Centrosome:AURKA:AJUBA [cytosol]

Physical Entity
Centrosome:AURKA:AJUBA [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AJUBA facilitates AURKA autophosphorylation (Bos taurus)
AJUBA facilitates AURKA autophosphorylation (Canis familiaris)
AJUBA facilitates AURKA autophosphorylation (Danio rerio)
AJUBA facilitates AURKA autophosphorylation (Gallus gallus)
AJUBA facilitates AURKA autophosphorylation (Mus musculus)
AJUBA facilitates AURKA autophosphorylation (Rattus norvegicus)
AJUBA facilitates AURKA autophosphorylation (Sus scrofa)
AJUBA facilitates AURKA autophosphorylation (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-01-29)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2012-11-12)
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