Reactome | NAPA [cytosol]

NAPA [cytosol]

Stable Identifier

R-HSA-264469

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Alpha-soluble NSF attachment protein, SNAA_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O75379 VAMP4

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External Reference Information

External Reference

UniProt:P54920 NAPA

Gene Names

NAPA, SNAPA

Chain

chain:1-295

Reference Genes

BioGPS Gene:8775 NAPA

COSMIC (genes):NAPA NAPA

CTD Gene:8775 NAPA

dbSNP Gene:8775 NAPA

ENSEMBL:ENSG00000105402 NAPA

HGNC:7641 NAPA

KEGG:hsa:8775 NAPA

Monarch:8775 NAPA

NCBI Gene:8775 NAPA

OMIM:603215 NAPA

UCSC:P54920 NAPA

Reference Transcript

RefSeq:NM_003827.3 NAPA

Other Identifiers

11744101_s_at

11744824_a_at

11745116_a_at

11745117_x_at

16873751

206491_PM_s_at

206491_s_at

208751_PM_at

208751_at

36977_at

3866606

3866607

3866608

3866609

3866610

3866611

3866612

3866613

3866614

3866615

3866616

3866617

3866618

3866619

3866620

3866621

3866622

3866623

3866624

3866625

3866626

3866627

3866628

3866630

3866634

3866637

3866638

3866640

3866642

3866643

3866645

3866646

3866647

8037913

8775

A_23_P55990

GE59128

GO:0000149

GO:0005483

GO:0005515

GO:0005829

GO:0005886

GO:0006886

GO:0006891

GO:0007420

GO:0010807

GO:0015031

GO:0016020

GO:0016082

GO:0016192

GO:0019905

GO:0023052

GO:0030154

GO:0030182

GO:0035249

GO:0035494

GO:0043226

GO:0044877

GO:0045176

GO:0048856

GO:0060090

GO:0061024

GO:0061025

GO:0065003

GO:0070044

GO:0070062

GO:0098793

GO:0098978

HMNXSV003009256

HMNXSV003052741

ILMN_1713285

PH_hs_0027689

PH_hs_0031325

TC19001666.hg

TC19002531.hg

U39412_at

g12654654_3p_a_at

p26055

Participates

as a component of

BLOC-1 Complex [lysosomal membrane] (Homo sapiens)

as an input of

Formation Of Bloc-1 Complex (Homo sapiens)

as a member of

SNAPs [cytosol] (Homo sapiens)

Inferred To

snap-1 [cytosol] (Caenorhabditis elegans)

alphaSnap [cytosol] (Drosophila melanogaster)

snpA [cytosol] (Dictyostelium discoideum)

napa [cytosol] (Xenopus tropicalis)

NAPA [cytosol] (Bos taurus)

NAPA [cytosol] (Canis familiaris)

NAPA [cytosol] (Gallus gallus)

NAPA [cytosol] (Plasmodium falciparum)

NAPA [cytosol] (Sus scrofa)

SEC17 [cytosol] (Saccharomyces cerevisiae)

Napa [cytosol] (Mus musculus)

Napa [cytosol] (Rattus norvegicus)

napab [cytosol] (Danio rerio)

sec17 [cytosol] (Schizosaccharomyces pombe)

Cross References

OpenTargets

ENSG00000105402

ENSEMBL

ENST00000263354, ENSP00000263354

HPA

ENSG00000105402-NAPA

PRO

P54920

Pharos - Targets

P54920

GlyGen

P54920

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.779	5
UniProt:O00161 SNAP23	5	p-S95-SNAP23 [phagocytic vesicle membrane] (R-HSA-8863923) SNAP23 [phagocytic vesicle membrane] (R-HSA-8863966) SNAP23 [tertiary granule membrane] (R-HSA-6806141) SNAP23 [plasma membrane] (R-HSA-376345) SNAP23 [specific granule membrane] (R-HSA-6806157)	0.779	5
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.745	7
UniProt:P46459 NSF	1	NSF [cytosol] (R-HSA-264471)	0.744	4
UniProt:Q13190 STX5	5	STX5 [cytosol] (R-HSA-9613991) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [endoplasmic reticulum membrane] (R-HSA-5689474)	0.738	5
UniProt:Q99747 NAPG	1	NAPG [cytosol] (R-HSA-5688555)	0.725	7
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.725	6
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.725	6
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.643	4
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.643	4
UniProt:Q9P2W9 STX18	1	STX18 [endoplasmic reticulum membrane] (R-HSA-2029079)	0.643	4
UniProt:Q9UNK0 STX8			0.643	6
UniProt:O14662 STX16	2	STX16 [Golgi membrane] (R-HSA-6811001) STX16 [trans-Golgi network membrane] (R-HSA-6811002)	0.643	3
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.643	4
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.643	4
UniProt:Q86Y82 STX12			0.643	6
UniProt:O60499 STX10	1	STX10 [trans-Golgi network membrane] (R-HSA-6810999)	0.643	3
UniProt:Q9NRW7 VPS45	2	VPS45 [Golgi membrane] (R-HSA-6811025) VPS45 [endosome membrane] (R-HSA-1011607)	0.643	3
UniProt:O15400 STX7			0.643	5
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.643	4
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.643	3
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.643	5
UniProt:Q96AJ9 VTI1A	2	VTI1A [trans-Golgi network membrane] (R-HSA-6813927) VTI1A [Golgi membrane] (R-HSA-6811035)	0.643	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:O43264 ZW10	1	ZW10 [cytosol] (R-HSA-377880)	0.527	2
UniProt:P0DTD8 NS7B			0.527	2
UniProt:O15498 YKT6	5	PalmC-YKT6 [Golgi membrane] (R-HSA-6808792) PalmC-YKT6 [transport vesicle] (R-HSA-6808794) PalmC-YKT6 [endoplasmic reticulum membrane] (R-HSA-5688145) PalmC-YKT6 [ER to Golgi transport vesicle membrane] (R-HSA-5688557) PalmC-YKT6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688558)	0.527	2
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425) VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129)	0.527	2
UniProt:A2RRP1 NBAS	1	NBAS [cytosol] (R-HSA-6810973)	0.527	2
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.527	2
UniProt:O95249 GOSR1	2	GOSR1 [transport vesicle] (R-HSA-6784834) GOSR1 [Golgi membrane] (R-HSA-6807753)	0.527	3
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.527	2
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.527	2
UniProt:Q9BV40 VAMP8	11	VAMP8 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869137) VAMP8 [secretory granule membrane] (R-HSA-376368) VAMP8 [cytoplasmic vesicle membrane] (R-HSA-376373) VAMP8 [Golgi membrane] (R-HSA-266201) VAMP8 [lysosomal membrane] (R-HSA-432710) VAMP8 [phagocytic vesicle membrane] (R-HSA-8863896) VAMP8 [recycling endosome membrane] (R-HSA-8863891) VAMP8 [tertiary granule membrane] (R-HSA-6801024) VAMP8 [specific granule membrane] (R-HSA-6799707) VAMP8 [plasma membrane] (R-HSA-376365) VAMP8 [azurophil granule membrane] (R-HSA-6799703)	0.527	2
UniProt:Q8WU76 SCFD2			0.527	2
UniProt:O95183 VAMP5			0.527	3
UniProt:P51809 VAMP7	6	VAMP7 [late endosome membrane] (R-HSA-2193120) VAMP7 [lysosomal membrane] (R-HSA-376342) VAMP7 [plasma membrane] (R-HSA-376361) VAMP7 [Golgi membrane] (R-HSA-266197) VAMP7 [cytoplasmic vesicle membrane] (R-HSA-376336) VAMP7 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869135)	0.527	2

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