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ARRB1 [cytosol]
Stable Identifier
R-HSA-264470
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Beta-arrestin-1, ARRB1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P23528 CFL1
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
F2R binds ARRB1 (Homo sapiens)
ARRB1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
ARRB1 [cytosol] (Homo sapiens)
trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
ARRB1 [cytosol] (Homo sapiens)
Lysosome Vesicle Biogenesis (Homo sapiens)
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Homo sapiens)
ARRB1 [cytosol] (Homo sapiens)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)
ARRB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49407 ARRB1
Gene Names
ARRB1, ARR1
Chain
chain:1-418
Reference Genes
BioGPS Gene:408 ARRB1
COSMIC (genes):ARRB1 ARRB1
CTD Gene:408 ARRB1
dbSNP Gene:408 ARRB1
ENSEMBL:ENSG00000137486 ARRB1
ENSEMBL_homo_sapiens_GENE:ENSG00000137486.17 ARRB1
HGNC:711 ARRB1
KEGG Gene (Homo sapiens):408 ARRB1
Monarch:408 ARRB1
NCBI Gene:408 ARRB1
OMIM:107940 ARRB1
UCSC:P49407 ARRB1
Reference Transcript
RefSeq:NM_004041.4 ARRB1
RefSeq:NM_020251.3 ARRB1
Other Identifiers
11742838_at
11760185_s_at
16742202
218832_PM_x_at
218832_x_at
221861_PM_at
221861_at
222756_PM_s_at
222756_s_at
222912_PM_at
222912_at
228444_PM_at
228444_at
3382217
3382218
3382219
3382220
3382221
3382222
3382224
3382225
3382230
3382231
3382233
3382234
3382236
3382239
3382241
3382243
3382246
3382247
3382252
3382278
3382279
3382280
408
43511_PM_s_at
43511_s_at
49111_PM_at
49111_at
58259_at
59336_at
7950473
A_23_P203702
A_24_P386622
GE54737
GE87006
GO:0000139
GO:0000785
GO:0001664
GO:0001934
GO:0002031
GO:0002092
GO:0003713
GO:0004857
GO:0005096
GO:0005159
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005794
GO:0005829
GO:0005886
GO:0005905
GO:0006351
GO:0006355
GO:0006357
GO:0006511
GO:0007010
GO:0007165
GO:0007601
GO:0009968
GO:0015031
GO:0016020
GO:0016192
GO:0016567
GO:0016604
GO:0023052
GO:0030163
GO:0030659
GO:0031143
GO:0031397
GO:0031410
GO:0031625
GO:0031701
GO:0032088
GO:0032715
GO:0032717
GO:0035025
GO:0036211
GO:0042995
GO:0043149
GO:0043161
GO:0043226
GO:0045746
GO:0045944
GO:0050877
GO:0070374
GO:0098772
GO:0140110
GO:1990763
HMNXSV003025489
HMNXSV003033637
Hs.112278.0.S2_3p_at
Hs.112278.0.S2_3p_x_at
Hs.112278.2.A1_3p_at
Hs.22483.0.S1_3p_at
Hs.22483.0.S1_3p_s_at
ILMN_1730620
ILMN_1819608
ILMN_1875302
ILMN_2325168
PH_hs_0006154
TC11002092.hg
g10880135_3p_a_at
Participates
as an input of
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Homo sapiens)
F2R binds ARRB1 (Homo sapiens)
as an output of
trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)
as a candidate of
CCP110,ARRB2,(ARRB1) [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
as a component of
F2R:ARRB1 [plasma membrane] (Homo sapiens)
as a member of
ARRB [cytosol] (Homo sapiens)
Other forms of this molecule
PolyUb-ARRB1 [cytosol]
ARRB1 [endocytic vesicle membrane]
ARRB1 [lysosomal membrane]
ARRB1 [Golgi membrane]
ARRB1 [cytoplasmic vesicle membrane]
Inferred To
Arr2 [cytosol]
(Drosophila melanogaster)
arr-1 [cytosol]
(Caenorhabditis elegans)
krz [cytosol]
(Drosophila melanogaster)
Ghost homologue of ARRB1 [cytosol]
(Gallus gallus)
arrb1 [cytosol]
(Danio rerio)
arrb1 [cytosol]
(Xenopus tropicalis)
Homologues of ARRB1 [cytosol]
(Drosophila melanogaster)
ARRB1 [cytosol]
(Bos taurus)
ARRB1 [cytosol]
(Canis familiaris)
ARRB1 [cytosol]
(Rattus norvegicus)
ARRB1 [cytosol]
(Sus scrofa)
Arr1 [cytosol]
(Drosophila melanogaster)
Arrb1 [cytosol]
(Mus musculus)
CG15303 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_004032.2
,
NP_064647.1
OpenTargets
ENSG00000137486
GeneCards
P49407
HPA
ENSG00000137486-ARRB1
Ensembl
ENST00000420843
,
ENSP00000353124
,
ENST00000360025
,
ENSP00000409581
,
ENSG00000137486
PRO
P49407
Pharos - Targets
P49407
PDB
8AS2
,
8JRV
,
8AS4
,
6UP7
,
7R0C
,
8AS3
,
6TKO
,
6PWC
,
7R0J
,
2IV8
,
7SRS
,
8WRZ
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14749 GNMT
1
GNMT [cytosol]
(R-HSA-5357674)
0.893
12
UniProt:P45984 MAPK9
3
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.841
9
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.744
10
UniProt:O43298 ZBT43
0.742
5
UniProt:Q14978 NOLC1
0.723
7
UniProt:P20963 CD247
0.644
9
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.641
3
UniProt:Q13428 TCOF
0.641
4
UniProt:O95218 ZRAB2
0.641
5
UniProt:Q5JWF2 GNAS
1
GNAS1 [plasma membrane]
(R-HSA-8873940)
0.639
5
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.623
3
UniProt:P53779 MAPK10
3
MAPK10 [cytosol]
(R-HSA-450352)
p-T221,Y223-MAPK10 [cytosol]
(R-HSA-450214)
p-T221,Y223-MAPK10 [nucleoplasm]
(R-HSA-450311)
0.609
2
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.602
4
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.577
3
UniProt:P36575 ARRC
0.564
3
UniProt:Q92541 RTF1
1
RTF1 [nucleoplasm]
(R-HSA-8866693)
0.564
2
UniProt:Q7Z4V5 HDGR2
0.564
3
UniProt:P63010-2 AP2B1
0.556
3
IntAct:EBI-22312375 CCSB ORF ID
0.556
3
UniProt:P14859-6 POU2F1
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.547
2
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.544
3
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.527
4
UniProt:P10523 SAG
1
SAG [cytosol]
(R-HSA-50320)
0.527
4
UniProt:P50148 GNAQ
1
GNAQ [plasma membrane]
(R-HSA-55453)
0.524
2
UniProt:Q7DB77 TIR
0.508
3
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.499
2
UniProt:P97288
1
Htr4 [plasma membrane]
(R-MMU-391008)
0.499
5
UniProt:P62158 CALM
0.499
3
UniProt:P14618 PKM
3
PKM [secretory granule lumen]
(R-HSA-6801401)
PKM [extracellular region]
(R-HSA-6806491)
PKM [ficolin-1-rich granule lumen]
(R-HSA-6801387)
0.499
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.499
3
UniProt:Q15208 STK38
1
STK38 [cytosol]
(R-HSA-9715143)
0.499
3
UniProt:P06702 S100A9
3
S100A9 [secretory granule lumen]
(R-HSA-6804774)
S100A9 [cytosol]
(R-HSA-9626869)
S100A9 [extracellular region]
(R-HSA-5432857)
0.499
2
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.499
3
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.499
4
UniProt:P19338 NCL
3
NCL [plasma membrane]
(R-HSA-9836466)
NCL [macropinosome membrane]
(R-HSA-9837666)
NCL [nucleoplasm]
(R-HSA-6791213)
0.499
3
UniProt:P35813 PPM1A
2
PPM1A [cytosol]
(R-HSA-380928)
PPM1A [nucleoplasm]
(R-HSA-205813)
0.499
4
UniProt:O75688 PPM1B
3
PPM1B [cytosol]
(R-HSA-1169375)
PPM1B(2-282)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713477)
PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713479)
0.499
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.499
5
UniProt:P25101 EDNRA
1
EDNRA [plasma membrane]
(R-HSA-388549)
0.499
3
UniProt:Q00610 CLTC
10
CLTC [trans-Golgi network membrane]
(R-HSA-5333703)
CLTC [cytosol]
(R-HSA-8856820)
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol]
(R-HSA-9710852)
CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710854)
CLTC [plasma membrane]
(R-HSA-2980668)
CLTC [lysosomal membrane]
(R-HSA-2980660)
CLTC [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138450)
CLTC [endolysosome membrane]
(R-HSA-8870827)
CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710853)
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9710835)
0.491
3
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.463
3
UniProt:P25106 ACKR3
1
CXCR7 [plasma membrane]
(R-HSA-373859)
0.463
2
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