Reactome | NSF [cytosol]

NSF [cytosol]

Stable Identifier

R-HSA-264471

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Vesicle-fusing ATPase, NSF_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O75379 VAMP4

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors to synapse (Homo sapiens)
        
        NSF [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46459 NSF

Gene Names

NSF

Chain

chain:1-744

Reference Genes

BioGPS Gene:4905 NSF

COSMIC (genes):NSF NSF

CTD Gene:4905 NSF

dbSNP Gene:4905 NSF

ENSEMBL:ENSG00000073969 NSF

HGNC:8016 NSF

KEGG:hsa:4905 NSF

Monarch:4905 NSF

NCBI Gene:4905 NSF

OMIM:601633 NSF

UCSC:P46459 NSF

Reference Transcript

RefSeq:NM_006178.3 NSF

Other Identifiers

11716972_s_at

11716973_a_at

11748462_a_at

16835064

16835087

16850337

202395_PM_at

202395_at

3723994

3723996

3724010

3724014

3724018

3724024

3724026

3724032

3724036

3724038

3724040

3724042

3724044

3724062

3724064

3724072

3724074

3724076

3724082

3724200

3724201

3724211

3724213

3724215

3724217

3724218

3724221

3724223

3724224

3724225

3724233

3724234

3724236

3724237

3724238

3724239

3724240

3724242

3724243

3724244

3724245

3724246

3724249

3724251

3724252

3724261

3724262

3724264

3724265

3724266

3724267

3724268

38719_at

4905

8007885

A_14_P125270

A_21_P0000605

A_23_P15714

A_24_P221634

A_33_P3284108

GE58871

GO:0000149

GO:0001921

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005765

GO:0005794

GO:0005795

GO:0005829

GO:0005886

GO:0006813

GO:0006886

GO:0006887

GO:0006891

GO:0014069

GO:0015031

GO:0016192

GO:0016787

GO:0016887

GO:0017075

GO:0017157

GO:0019901

GO:0019905

GO:0030165

GO:0035255

GO:0035494

GO:0043001

GO:0043198

GO:0043226

GO:0044877

GO:0045026

GO:0045732

GO:0046872

GO:0061024

GO:0072659

GO:0140545

GO:0140657

HMNXSV003023638

HMNXSV003029563

HMNXSV003035586

ILMN_1662892

ILMN_1680353

ILMN_1680687

ILMN_1752606

ILMN_2330845

PH_hs_0025223

TC17000598.hg

TC17000600.hg

TC17002245.hg

TC17002247.hg

TC17_ctg5_hap1000010.hg

TC17_ctg5_hap1000015.hg

g11079227_3p_at

Participates

as a component of

NSF hexamer [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of NSF [cytosol] (Xenopus tropicalis)

NSF [cytosol] (Bos taurus)

NSF [cytosol] (Caenorhabditis elegans)

NSF [cytosol] (Canis familiaris)

NSF [cytosol] (Dictyostelium discoideum)

NSF [cytosol] (Drosophila melanogaster)

NSF [cytosol] (Gallus gallus)

NSF [cytosol] (Mus musculus)

NSF [cytosol] (Plasmodium falciparum)

NSF [cytosol] (Rattus norvegicus)

NSF [cytosol] (Saccharomyces cerevisiae)

NSF [cytosol] (Schizosaccharomyces pombe)

NSF [cytosol] (Sus scrofa)

nsfb [cytosol] (Danio rerio)

Cross References

RefSeq

NP_006169.2

OpenTargets

ENSG00000073969

ENSEMBL

ENSP00000481714, ENSP00000478614, ENST00000611398, ENST00000620290, ENSP00000516369, ENST00000398238, ENSP00000381293, ENST00000706392

HPA

ENSG00000073969-NSF

PRO

P46459

Pharos - Targets

P46459

GlyGen

P46459

PDB

6KZQ

HMDB Protein

HMDBP01424

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.744	4
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.643	3
UniProt:Q86Y82 STX12			0.643	3
UniProt:Q99747 NAPG	1	NAPG [cytosol] (R-HSA-5688555)	0.643	3
UniProt:O75899 GABBR2	1	GABBR2 [plasma membrane] (R-HSA-420747)	0.611	4
UniProt:Q9UBS5 GABBR1	1	GABBR1 [plasma membrane] (R-HSA-420716)	0.571	3
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.569	3
UniProt:Q9H477 RBKS	1	RBKS [cytosol] (R-HSA-8955847)	0.564	2
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.544	2
UniProt:P42262 GRIA2	3	GRIA2 [plasma membrane] (R-HSA-3004502) p-S880-GRIA2 [plasma membrane] (R-HSA-3004500) GRIA2 [endocytic vesicle membrane] (R-HSA-3004487)	0.544	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P59635 7a	4	7a [plasma membrane] (R-COV-9735855) 7a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9686193) 7a [endocytic vesicle membrane] (R-COV-9686695) 7a [virion membrane] (R-COV-9678204)	0.527	2
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.527	2
UniProt:O15400 STX7			0.527	2
UniProt:Q9UNK0 STX8			0.527	2
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.527	2
UniProt:O95249 GOSR1	2	GOSR1 [transport vesicle] (R-HSA-6784834) GOSR1 [Golgi membrane] (R-HSA-6807753)	0.527	2
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.527	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.508	2

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