Reactome | DNAJC6 [cytosol]

DNAJC6 [cytosol]

Stable Identifier

R-HSA-264472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Putative tyrosine-protein phosphatase auxilin, AUXI_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GAK,DNAJC6 [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
  - trans-Golgi Network Vesicle Budding (Homo sapiens)
    - Golgi Associated Vesicle Biogenesis (Homo sapiens)
      - trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
        
        HSC70:Auxillin Complex [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)
    - Lysosome Vesicle Biogenesis (Homo sapiens)
      - trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)
        
        HSC70:Auxillin Complex [cytosol] (Homo sapiens)
        
        DNAJC6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75061 DNAJC6

Gene Names

DNAJC6, KIAA0473

Chain

chain:1-913

Reference Genes

BioGPS Gene:9829 DNAJC6

COSMIC (genes):DNAJC6 DNAJC6

CTD Gene:9829 DNAJC6

dbSNP Gene:9829 DNAJC6

ENSEMBL:ENSG00000116675 DNAJC6

HGNC:15469 DNAJC6

Monarch:9829 DNAJC6

NCBI Gene:9829 DNAJC6

OMIM:608375 DNAJC6

UCSC:O75061 DNAJC6

Reference Transcript

Other Identifiers

11745300_a_at

11745301_a_at

11745939_a_at

16665687

204720_PM_s_at

204720_s_at

204721_PM_s_at

204721_s_at

2340351

2340352

2340357

2340361

2340362

2340363

2340364

2340365

2340375

2340376

2340377

2340378

2340379

2340381

2340382

2340383

2340384

2340385

2340386

2340387

2340388

2340389

2340390

2340391

2340392

2340393

2340394

2340395

2340396

2340398

2340399

2340401

2340402

2340403

2340404

2340405

2340406

36022_at

7902043

9829

A_14_P125278

A_14_P133959

A_23_P147479

A_23_P95359

A_33_P3216714

GE53207

GO:0003824

GO:0004721

GO:0004725

GO:0005515

GO:0005737

GO:0005829

GO:0014069

GO:0016191

GO:0016192

GO:0016311

GO:0016787

GO:0017124

GO:0030136

GO:0030276

GO:0031072

GO:0031410

GO:0031982

GO:0032050

GO:0036465

GO:0043226

GO:0043231

GO:0045202

GO:0046907

GO:0072318

GO:0072583

GO:0098894

GO:0140096

GO:1905443

GO:2000369

HMNXSV003017053

Hs.44896.0.S1_3p_a_at

ILMN_1696079

ILMN_2166543

PH_hs_0003254

TC01000729.hg

g7662145_3p_a_at

Participates

as a member of

GAK,DNAJC6 [cytosol] (Homo sapiens)

as a component of

HSC70:Auxillin Complex [cytosol] (Homo sapiens)

Inferred To

ucp7 [cytosol] (Schizosaccharomyces pombe)

Dnajc6 [cytosol] (Mus musculus)

Dnajc6 [cytosol] (Rattus norvegicus)

dnajc6 [cytosol] (Xenopus tropicalis)

Homologues of DNAJC6 [cytosol] (Plasmodium falciparum)

DNAJC6 [cytosol] (Bos taurus)

DNAJC6 [cytosol] (Canis familiaris)

DNAJC6 [cytosol] (Dictyostelium discoideum)

DNAJC6 [cytosol] (Gallus gallus)

DNAJC6 [cytosol] (Plasmodium falciparum)

DNAJC6 [cytosol] (Sus scrofa)

dnj-25 [cytosol] (Caenorhabditis elegans)

SWA2 [cytosol] (Saccharomyces cerevisiae)

Cross References

ENSEMBL

ENSP00000263441, ENSP00000378735, ENST00000395325, ENST00000263441, ENSP00000360108, ENST00000371069

OpenTargets

ENSG00000116675

HPA

ENSG00000116675-DNAJC6

PRO

O75061

Pharos - Targets

O75061

Orphanet

DNAJC6

HMDB Protein

HMDBP08897

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4

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