Reactome | HSPA8 [cytosol]

HSPA8 [cytosol]

Stable Identifier

R-HSA-264476

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Heat shock cognate 71 kDa protein, HSP7C_HUMAN, HSC70

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
      - PKR-mediated signaling (Homo sapiens)
        
        FA core complex:HSP70s binds PKR (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        HSP70 proteins [cytosol] (Homo sapiens)
        
        HSPA8 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        HSP70 proteins [cytosol] (Homo sapiens)
        
        HSPA8 [cytosol] (Homo sapiens)
        
        PKR forms a dimer (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        HSP70 proteins [cytosol] (Homo sapiens)
        
        HSPA8 [cytosol] (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
      - Expression of HSPA8, ALOX15 (Homo sapiens)
        
        HSPA8, ALOX15 [cytosol] (Homo sapiens)
        
        HSPA8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11142 HSPA8

Gene Names

HSPA8, HSC70, HSP73, HSPA10

Chain

initiator methionine:1, chain:2-646

Reference Genes

BioGPS Gene:3312 HSPA8

COSMIC (genes):HSPA8 HSPA8

CTD Gene:3312 HSPA8

dbSNP Gene:3312 HSPA8

ENSEMBL:ENSG00000109971 HSPA8

ENSEMBL:ENSG00000109971.14 HSPA8

HGNC:5241 HSPA8

KEGG Gene (Homo sapiens):3312 HSPA8

Monarch:3312 HSPA8

NCBI Gene:3312 HSPA8

OMIM:600816 HSPA8

UCSC:P11142 HSPA8

Reference Transcript

Other Identifiers

11720916_s_at

11741210_a_at

11741211_x_at

11756622_a_at

11762261_x_at

1179_at

1180_g_at

16745525

208687_PM_x_at

208687_x_at

210338_PM_s_at

210338_s_at

221891_PM_x_at

221891_x_at

224187_PM_x_at

224187_x_at

2989994

3011035

3312

33820_g_at

3395420

3395421

3395422

3395424

3395427

3395428

3395432

3395433

3395437

3395438

3395439

3395441

3395442

3395444

3395445

3395449

3395450

3395452

3395453

3395454

3395455

3401658

4020036

4020040

4020043

4020046

40637_at

44833_s_at

73372_r_at

7952325

A_23_P24594

A_24_P287129

A_24_P295745

A_32_P13728

A_33_P3390758

GE79248

GO:0000166

GO:0000398

GO:0000974

GO:0001664

GO:0001786

GO:0003723

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005776

GO:0005829

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0006397

GO:0006457

GO:0006886

GO:0006914

GO:0006986

GO:0007018

GO:0008289

GO:0008380

GO:0009267

GO:0016020

GO:0016071

GO:0016192

GO:0016787

GO:0016887

GO:0019899

GO:0023026

GO:0030163

GO:0030425

GO:0030674

GO:0031072

GO:0031410

GO:0031625

GO:0031647

GO:0034330

GO:0034774

GO:0042026

GO:0042470

GO:0043195

GO:0043202

GO:0043226

GO:0043254

GO:0044183

GO:0044788

GO:0044829

GO:0045296

GO:0045892

GO:0046034

GO:0048026

GO:0048471

GO:0051082

GO:0051085

GO:0051087

GO:0051726

GO:0055086

GO:0055131

GO:0060090

GO:0061024

GO:0061077

GO:0061202

GO:0061635

GO:0061684

GO:0061738

GO:0061740

GO:0065003

GO:0070062

GO:0071383

GO:0072318

GO:0072562

GO:0098575

GO:0098684

GO:0098690

GO:0098793

GO:0098978

GO:0099175

GO:0099523

GO:0099524

GO:0099634

GO:0101031

GO:0140104

GO:0140545

GO:0140597

GO:0140657

GO:0140662

GO:1900226

GO:1901135

GO:1902904

GO:1904589

GO:1904764

GO:1904813

GO:1990832

GO:1990833

GO:1990904

HMNXSV003019988

Hs.180414.3.A1_3p_a_at

ILMN_1686367

ILMN_2413084

PH_hs_0039202

PH_hs_0040139

TC11002390.hg

g11526572_3p_a_at

Participates

as a component of

as an input of

as a member of

as an output of

Other forms of this molecule

Me3K561-HSPA8 [nucleoplasm]

HSPA8 [secretory granule lumen]

HSPA8 [extracellular region]

HSPA8 [ficolin-1-rich granule lumen]

HSPA8 [nucleoplasm]

HSPA8 [plasma membrane]

HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

HSPA8 [late endosome lumen]

HSPA8 [lysosomal lumen]

Inferred To

si:dkey-4p15.3 [cytosol] (Danio rerio)

hsp-1 [cytosol] (Caenorhabditis elegans)

hspB [cytosol] (Dictyostelium discoideum)

ssa1 [cytosol] (Schizosaccharomyces pombe)

Homologues of HSPA8 [cytosol] (Danio rerio)

Hsc70-4 [cytosol] (Drosophila melanogaster)

HSPA8 [cytosol] (Bos taurus)

HSPA8 [cytosol] (Canis familiaris)

HSPA8 [cytosol] (Gallus gallus)

HSPA8 [cytosol] (Mus musculus)

HSPA8 [cytosol] (Rattus norvegicus)

HSPA8 [cytosol] (Sus scrofa)

SSA2 [cytosol] (Saccharomyces cerevisiae)

hspa8 [cytosol] (Danio rerio)

hspa8 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011541100.1, NP_006588.1, NP_694881.1

Guide to Pharmacology - Targets

2543

OpenTargets

ENSG00000109971

ZINC - Substances

HSP7C_HUMAN

ZINC target

P11142

ZINC - Biogenic

HSP7C_HUMAN

PRO

P11142

PDB

5AQI, 4H5N, 5AQJ, 4HWI, 3ESK, 5AQR, 5AQH, 3FZK, 5AQQ, 3FZL, 5AQL, 5AQT, 4H5R, 3FZM, 5AQK, 3AGY, 5AQS, 4KBQ, 4H5T, 6ZYJ, 5AQN, 3FZF, 5AQV, 6B1I, 3AGZ, 5AQM, 5AQU, 3M3Z, 5AQG, 5AQP, 6B1N, 5AQF, 4H5W, 5AQO, 3FZH, 3LDQ, 6B1M, 4H5V

ZINC - Metabolites

HSP7C_HUMAN

HPA

ENSG00000109971-HSPA8

GeneCards

P11142

Ensembl

ENSP00000437125, ENSP00000227378, ENSP00000432083, ENSG00000109971, ENST00000453788, ENSP00000404372, ENST00000534624, ENST00000532636, ENST00000227378

Pharos - Targets

P11142

ZINC - Predictions - Purchasable

HSP7C_HUMAN

Orphanet

24608

HMDB Protein

HMDBP13799

Interactors (64)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZL4 HPBP1			0.859	12
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.832	8
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.813	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.803	7
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.772	8
UniProt:P34932 HSPA4	2	HSPA4 [cytosol] (R-HSA-5251946) HSPA4 [nucleoplasm] (R-HSA-5251998)	0.727	6
UniProt:Q99933 BAG1	1	BAG1 [cytosol] (R-HSA-5255443)	0.719	13
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.718	6
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.709	5
UniProt:O14976 GAK	3	GAK [cytoplasmic vesicle membrane] (R-HSA-434203) GAK [Golgi membrane] (R-HSA-434340) GAK [cytosol] (R-HSA-8868619)	0.695	7
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.666	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	14
UniProt:P54253 ATX1			0.666	13
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	8
UniProt:Q8TDR0 TRAF3IP1	2	TRAF3IP1 [ciliary tip] (R-HSA-5625404) TRAF3IP1 [cilium] (R-HSA-5617603)	0.664	5
UniProt:P00338 LDHA	1	LDHA [cytosol] (R-HSA-70502)	0.639	4
UniProt:P38260 FES1			0.61	4
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.597	3
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.573	2
UniProt:Q99IB8-PRO_0000045603			0.57	3
UniProt:Q3B7T1 EDRF1			0.569	4
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.569	4
UniProt:Q99615 DNAJC7	2	DNAJC7 [cytosol] (R-HSA-5252099) DNAJC7 [nucleoplasm] (R-HSA-5255408)	0.569	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.569	4
UniProt:Q9UL15 BAG5	1	BAG5 [cytosol] (R-HSA-5255453)	0.569	8
UniProt:O75165 DNAJC13	3	DNAJC13 [azurophil granule membrane] (R-HSA-6799140) DNAJC13 [plasma membrane] (R-HSA-6806255) DNAJC13 [secretory granule membrane] (R-HSA-6800951)	0.569	4
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.564	3
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.564	2
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.564	2
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.564	2
UniProt:Q9BQI3 EIF2AK1	2	p-T-EIF2AK1 [cytosol] (R-HSA-9648892) p-T,T486,T488-EIF2AK1 [cytosol] (R-HSA-9648894)	0.564	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.564	3
UniProt:P01308-PRO_0000015820 INS			0.558	2
UniProt:P10636-6 MAPT			0.558	3
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.558	5
UniProt:P01893 HLA-H	8	HLA-H [early endosome membrane] (R-HSA-8855898) HLA-H [phagocytic vesicle membrane] (R-HSA-8855901) HLA-H [recycling endosome membrane] (R-HSA-8863855) HLA-H [Golgi membrane] (R-HSA-8855895) HLA-H [ER to Golgi transport vesicle membrane] (R-HSA-8855892) HLA-H [plasma membrane] (R-HSA-6806266) HLA-H [azurophil granule membrane] (R-HSA-6799339) HLA-H [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-8855907)	0.558	2
UniProt:O60260-5 PRKN			0.556	9
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.547	2
UniProt:Q99592 ZBT18			0.527	2
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.527	3
UniProt:Q38SD2 LRRK1			0.527	2
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	2
UniProt:Q9NVT9 ARMC1			0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.527	2
UniProt:P63092 GNAS	1	GNAS2 [plasma membrane] (R-HSA-164387)	0.527	2
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.527	2
UniProt:P03485 M	6	M1 [plasma membrane] (R-FLU-195782) M1 [extracellular region] (R-FLU-169241) M1 [endocytic vesicle membrane] (R-FLU-189168) M1 [endosome lumen] (R-FLU-189155) M1 [cytosol] (R-FLU-169073) M1 [nucleoplasm] (R-FLU-186959)	0.524	4
UniProt:Q9NQ11 ATP13A2	1	ATP13A2 [lysosomal lumen] (R-HSA-939762)	0.508	2
UniProt:Q8AZK7 EBNA5			0.499	3
UniProt:P49407 ARRB1	5	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	4
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.499	2
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.499	2
UniProt:P14598 NCF1	4	NCF1 [cytosol] (R-HSA-1222296) p-6S-NCF1 [phagolysosome] (R-HSA-1996220) p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854)	0.499	2
UniProt:P32121 ARRB2	2	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000)	0.499	4
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.499	2
UniProt:Q99IB8-PRO_0000045599			0.488	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	14
UniProt:O75190 DNAJB6	2	DNAJB6 [cytosol] (R-HSA-5252014) DNAJB6 [nucleoplasm] (R-HSA-5255425)	0.482	2
UniProt:O95801 TTC4			0.482	2

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