Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HSPA8 [cytosol]
Stable Identifier
R-HSA-264476
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Heat shock cognate 71 kDa protein, HSP7C_HUMAN, HSC70
Icon
Locations in the PathwayBrowser for interactor UniProt:P36507 MAP2K2
Expand all
Autophagy (Homo sapiens)
Chaperone Mediated Autophagy (Homo sapiens)
HSPA8 binds LAMP2a multimers (Homo sapiens)
HSPA8 [cytosol] (Homo sapiens)
HSPA8 binds substrate (Homo sapiens)
HSPA8 [cytosol] (Homo sapiens)
HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)
HSPA8 [cytosol] (Homo sapiens)
HSPA8 dissociates from LAMP2a (Homo sapiens)
HSPA8 [cytosol] (Homo sapiens)
Late endosomal microautophagy (Homo sapiens)
HSPA8 binds substrate (Homo sapiens)
HSPA8 [cytosol] (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Lipophagy (Homo sapiens)
PLINs bind HSPA8 (Homo sapiens)
HSPA8 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
CHL1 interactions (Homo sapiens)
CHL1 interacts with HSP7C (Homo sapiens)
HSPA8 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Respiratory syncytial virus genome transcription (Homo sapiens)
Transcription of respiratory syncytial virus subgenomic positive sense mRNAs (Homo sapiens)
HSPA8 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1 binds translation and heat shock proteins (Homo sapiens)
HSPA8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11142 HSPA8
Gene Names
HSPA8, HSC70, HSP73, HSPA10
Chain
initiator methionine:, chain:2-646
Reference Genes
BioGPS Gene:3312 HSPA8
COSMIC (genes):HSPA8 HSPA8
CTD Gene:3312 HSPA8
dbSNP Gene:3312 HSPA8
ENSEMBL:ENSG00000109971 HSPA8
ENSEMBL_homo_sapiens_GENE:ENSG00000109971.14 HSPA8
HGNC:5241 HSPA8
KEGG Gene (Homo sapiens):3312 HSPA8
Monarch:3312 HSPA8
NCBI Gene:3312 HSPA8
OMIM:600816 HSPA8
UCSC:P11142 HSPA8
Reference Transcript
RefSeq:XM_011542798.1 HSPA8
RefSeq:NM_153201.3 HSPA8
RefSeq:NM_006597.5 HSPA8
Other Identifiers
11720916_s_at
11741210_a_at
11741211_x_at
11756622_a_at
11762261_x_at
1179_at
1180_g_at
16745525
208687_PM_x_at
208687_x_at
210338_PM_s_at
210338_s_at
221891_PM_x_at
221891_x_at
224187_PM_x_at
224187_x_at
2989994
3011035
3312
33820_g_at
3395420
3395421
3395422
3395424
3395427
3395428
3395432
3395433
3395437
3395438
3395439
3395441
3395442
3395444
3395445
3395449
3395450
3395452
3395453
3395454
3395455
3401658
4020036
4020040
4020043
4020046
40637_at
44833_s_at
73372_r_at
7952325
A_23_P24594
A_24_P287129
A_24_P295745
A_32_P13728
A_33_P3390758
GE79248
GO:0000166
GO:0000398
GO:0000974
GO:0001664
GO:0003723
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005681
GO:0005730
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005776
GO:0005829
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0006397
GO:0006457
GO:0006886
GO:0006914
GO:0006986
GO:0007018
GO:0008380
GO:0009267
GO:0016020
GO:0016071
GO:0016192
GO:0016787
GO:0016887
GO:0019899
GO:0023026
GO:0030163
GO:0030425
GO:0030674
GO:0031072
GO:0031410
GO:0031625
GO:0031647
GO:0034774
GO:0042026
GO:0042470
GO:0043195
GO:0043202
GO:0043226
GO:0043254
GO:0044183
GO:0045296
GO:0045892
GO:0046034
GO:0051082
GO:0051085
GO:0051087
GO:0055086
GO:0055131
GO:0060090
GO:0061024
GO:0061202
GO:0061635
GO:0061684
GO:0061738
GO:0061740
GO:0065003
GO:0070062
GO:0071383
GO:0072318
GO:0072562
GO:0098575
GO:0099523
GO:0099524
GO:0101031
GO:0140104
GO:0140545
GO:0140597
GO:0140657
GO:0140662
GO:1900226
GO:1901135
GO:1902904
GO:1904589
GO:1904764
GO:1904813
GO:1990832
GO:1990833
GO:1990904
HMNXSV003019988
Hs.180414.3.A1_3p_a_at
ILMN_1686367
ILMN_2413084
PH_hs_0039202
PH_hs_0040139
TC11002390.hg
g11526572_3p_a_at
Participates
as a component of
HSC70:Auxillin Complex [cytosol] (Homo sapiens)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Homo sapiens)
CHL1:HSP7C [plasma membrane] (Homo sapiens)
HSPA8:ADP [cytosol] (Homo sapiens)
HSPA8:ATP [cytosol] (Homo sapiens)
PLINs:HSPA8 [lipid droplet] (Homo sapiens)
p-PLINs:HSPA8 [cytosol] (Homo sapiens)
p-PLINs:HSPA8 [lipid droplet] (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
HSPA8:LAMP2a multimers [lysosomal membrane] (Homo sapiens)
as an input of
AUF1 binds translation and heat shock proteins (Homo sapiens)
CHL1 interacts with HSP7C (Homo sapiens)
PLINs bind HSPA8 (Homo sapiens)
HSPA8 binds substrate (Homo sapiens)
HSPA8 binds LAMP2a multimers (Homo sapiens)
as a member of
HSPA8, ALOX15 [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
as an output of
HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)
HSPA8 dissociates from LAMP2a (Homo sapiens)
This entity regulates
Positively
Transcription of respiratory syncytial virus subgenomic positive sense mRNAs
(Homo sapiens)
Other forms of this molecule
Me3K561-HSPA8 [nucleoplasm]
HSPA8 [secretory granule lumen]
HSPA8 [extracellular region]
HSPA8 [ficolin-1-rich granule lumen]
HSPA8 [nucleoplasm]
HSPA8 [plasma membrane]
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
HSPA8 [late endosome lumen]
HSPA8 [lysosomal lumen]
Inferred To
LOC607182 [cytosol]
(Canis familiaris)
hsp-1 [cytosol]
(Caenorhabditis elegans)
hspB [cytosol]
(Dictyostelium discoideum)
ssa1 [cytosol]
(Schizosaccharomyces pombe)
Homologues of HSPA8 [cytosol]
(Schizosaccharomyces pombe)
Hsc70-4 [cytosol]
(Drosophila melanogaster)
HSPA8 [cytosol]
(Bos taurus)
HSPA8 [cytosol]
(Danio rerio)
HSPA8 [cytosol]
(Gallus gallus)
HSPA8 [cytosol]
(Mus musculus)
HSPA8 [cytosol]
(Plasmodium falciparum)
HSPA8 [cytosol]
(Rattus norvegicus)
HSPA8 [cytosol]
(Sus scrofa)
ssa2 [cytosol]
(Schizosaccharomyces pombe)
SSA2 [cytosol]
(Saccharomyces cerevisiae)
hspa8 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_694881.1
,
XP_011541100.1
,
NP_006588.1
Guide to Pharmacology - Targets
2543
OpenTargets
ENSG00000109971
ZINC - Substances
HSP7C_HUMAN
ZINC target
P11142
ZINC - Biogenic
HSP7C_HUMAN
PRO
P11142
PDB
3FZF
,
4H5W
,
5AQM
,
3FZH
,
6ZYJ
,
5AQN
,
5AQV
,
3LDQ
,
5AQL
,
4H5V
,
6B1I
,
5AQU
,
3AGZ
,
5AQT
,
3AGY
,
4H5R
,
5AQK
,
4H5T
,
5AQJ
,
5AQS
,
3ESK
,
5AQQ
,
3FZM
,
5AQR
,
5AQH
,
4H5N
,
4KBQ
,
5AQI
,
4HWI
,
5AQO
,
3FZK
,
3FZL
,
5AQP
,
5AQF
,
3M3Z
,
6B1M
,
6B1N
,
5AQG
ZINC - Metabolites
HSP7C_HUMAN
HPA
ENSG00000109971-HSPA8
GeneCards
P11142
Ensembl
ENST00000453788
,
ENSG00000109971
,
ENST00000227378
,
ENSP00000437125
,
ENSP00000404372
,
ENST00000534624
,
ENSP00000227378
,
ENST00000532636
,
ENSP00000432083
Pharos - Targets
P11142
ZINC - Predictions - Purchasable
HSP7C_HUMAN
HMDB Protein
HMDBP13799
Interactors (160)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NZL4 HPBP1
0.924
15
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.871
9
UniProt:O95816 BAG2
1
BAG2 [cytosol]
(R-HSA-5255445)
0.823
10
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.813
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.803
7
UniProt:P34932 HSPA4
2
HSPA4 [cytosol]
(R-HSA-5251946)
HSPA4 [nucleoplasm]
(R-HSA-5251998)
0.787
7
UniProt:O14976 GAK
3
GAK [cytoplasmic vesicle membrane]
(R-HSA-434203)
GAK [Golgi membrane]
(R-HSA-434340)
GAK [cytosol]
(R-HSA-8868619)
0.763
9
UniProt:Q99933 BAG1
1
BAG1 [cytosol]
(R-HSA-5255443)
0.719
13
UniProt:O00635 TRIM38
1
TRIM38 [cytosol]
(R-HSA-5624325)
0.718
6
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.709
5
UniProt:Q3B7T1 EDRF1
0.671
6
UniProt:O75165 DNAJC13
3
DNAJC13 [secretory granule membrane]
(R-HSA-6800951)
DNAJC13 [plasma membrane]
(R-HSA-6806255)
DNAJC13 [azurophil granule membrane]
(R-HSA-6799140)
0.671
6
UniProt:O95817 BAG3
1
BAG3 [cytosol]
(R-HSA-5255451)
0.671
5
UniProt:P54652 HSPA2
2
HSPA2 [cytosol]
(R-HSA-3371408)
HSPA2 [nucleoplasm]
(R-HSA-912480)
0.671
6
UniProt:Q9UL15 BAG5
1
BAG5 [cytosol]
(R-HSA-5255453)
0.671
9
UniProt:Q15428 SF3A2
1
SF3A2 [nucleoplasm]
(R-HSA-71964)
0.669
4
UniProt:Q15750 TAB1
6
TAB1(445-504) [cytosol]
(R-HSA-9729691)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1 [cytosol]
(R-HSA-167923)
0.669
3
UniProt:P10636 MAPT
3
MAPT(422-758) [cytosol]
(R-HSA-350642)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT [cytosol]
(R-HSA-201574)
0.667
6
UniProt:P54253 ATX1
0.666
13
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.666
8
UniProt:O95429 BAG4
3
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.666
6
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
14
UniProt:Q8TDR0 TRAF3IP1
2
TRAF3IP1 [ciliary tip]
(R-HSA-5625404)
TRAF3IP1 [cilium]
(R-HSA-5617603)
0.664
5
UniProt:O15273 TCAP
1
TCAP [cytosol]
(R-HSA-390571)
0.659
4
UniProt:Q99592 ZBT18
0.643
3
UniProt:P36507 MAP2K2
12
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
0.643
5
UniProt:Q96CP2 FWCH2
0.643
3
UniProt:Q9NVT9 ARMC1
0.643
4
UniProt:P42684 ABL2
1
ABL2 [cytosol]
(R-HSA-375998)
0.643
3
UniProt:P00338 LDHA
2
PolyUb-LDHA [cytosol]
(R-HSA-9861549)
LDHA [cytosol]
(R-HSA-70502)
0.639
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
22
UniProt:P38260 FES1
0.61
4
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.597
3
UniProt:Q92731 ESR2
5
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.597
3
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB [nucleoplasm]
(R-HSA-3321990)
ACTB [cytosol]
(R-HSA-201861)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [plasma membrane]
(R-HSA-196016)
0.573
2
UniProt:Q99IB8-PRO_0000045603
0.57
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
11
UniProt:Q9BQC3 DPH2
1
DPH2 [cytosol]
(R-HSA-5358368)
0.569
4
UniProt:Q99615 DNAJC7
2
DNAJC7 [cytosol]
(R-HSA-5252099)
DNAJC7 [nucleoplasm]
(R-HSA-5255408)
0.569
3
UniProt:Q9H4A3 WNK1
1
WNK1 [cytosol]
(R-HSA-2672391)
0.569
5
UniProt:Q9BZG8 DPH1
1
DPH1 [cytosol]
(R-HSA-5358384)
0.569
4
UniProt:O95757 HSPA4L
2
HSPA4L [cytosol]
(R-HSA-5251943)
HSPA4L [nucleoplasm]
(R-HSA-5252053)
0.569
4
UniProt:Q9H6T0 ESRP2
1
ESRP2 [nucleoplasm]
(R-HSA-6803474)
0.564
2
UniProt:P57723 PCBP4
1
PCBP4 [cytosol]
(R-HSA-6803382)
0.564
2
UniProt:Q8IZP0 ABI1
2
p-5S-ABI1 [cytosol]
(R-HSA-2029034)
ABI1 [cytosol]
(R-HSA-1671643)
0.564
2
UniProt:Q14164 IKBKE
5
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
0.564
2
UniProt:Q9ULK5 VANGL2
2
VANGL2 [plasma membrane]
(R-HSA-3965373)
pS5,S82,S84-VANGL2 [plasma membrane]
(R-HSA-4551547)
0.564
2
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.564
3
UniProt:Q9BQI3 EIF2AK1
3
p-T-EIF2AK1 [cytosol]
(R-HSA-9648892)
p-T,T486,T488-EIF2AK1 [cytosol]
(R-HSA-9648894)
EIF2AK1 [cytosol]
(R-HSA-9840382)
0.564
2
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.564
3
UniProt:P50552 VASP
1
VASP [cytosol]
(R-HSA-446323)
0.564
2
UniProt:P01308-PRO_0000015820 INS
0.558
2
UniProt:P10636-6 MAPT
0.558
3
UniProt:P01893 HLA-H
8
HLA-H [azurophil granule membrane]
(R-HSA-6799339)
HLA-H [phagocytic vesicle membrane]
(R-HSA-8855901)
HLA-H [recycling endosome membrane]
(R-HSA-8863855)
HLA-H [early endosome membrane]
(R-HSA-8855898)
HLA-H [plasma membrane]
(R-HSA-6806266)
HLA-H [Golgi membrane]
(R-HSA-8855895)
HLA-H [ER to Golgi transport vesicle membrane]
(R-HSA-8855892)
HLA-H [lumenal side of endoplasmic reticulum membrane]
(R-HSA-8855907)
0.558
2
UniProt:O60260-5 PRKN
0.556
9
UniProt:P41220 RGS2
1
RGS2 [plasma membrane]
(R-HSA-939787)
0.553
2
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.547
2
UniProt:Q8N163 CCAR2
2
DBC1 [nucleoplasm]
(R-HSA-3371479)
p-T454-DBC1 [nucleoplasm]
(R-HSA-3371569)
0.547
2
UniProt:Q96MN9 ZN488
0.527
3
UniProt:Q99439 CNN2
3
CNN2 [specific granule lumen]
(R-HSA-6799532)
CNN2 [extracellular region]
(R-HSA-6806300)
CNN2 [tertiary granule lumen]
(R-HSA-6800942)
0.527
2
UniProt:Q9H9A6 LRC40
0.527
2
UniProt:Q00341 HDLBP
1
HDLBP [plasma membrane]
(R-HSA-8858026)
0.527
2
UniProt:Q96BH1 RNF25
1
RNF25 [cytosol]
(R-HSA-975976)
0.527
2
UniProt:P30679 GNA15
1
GNA15 [plasma membrane]
(R-HSA-167450)
0.527
2
UniProt:Q9Y2I8 WDR37
0.527
5
UniProt:Q6ZMN8 CCNI2
0.527
2
UniProt:Q15555 MARE2
0.527
3
UniProt:Q9BYJ1 ALOXE3
1
ALOXE3 [cytosol]
(R-HSA-8942204)
0.527
2
UniProt:P0DPA2 VSIG8
0.527
2
UniProt:Q9BXA7 TSSK1
0.527
2
UniProt:Q8IVL6 P3H3
1
LEPREL2 [endoplasmic reticulum lumen]
(R-HSA-1650821)
0.527
2
UniProt:Q5TEC6 H37
0.527
2
UniProt:P40121 CAPG
0.527
2
UniProt:Q9Y6J9 TAF6L
1
TAF6L [nucleoplasm]
(R-HSA-212393)
0.527
2
UniProt:Q53H47 SETMR
0.527
2
UniProt:P68871 HBB
8
CO-H+-HBB [cytosol]
(R-HSA-1237013)
HBB [ficolin-1-rich granule lumen]
(R-HSA-6801015)
HBB [tertiary granule lumen]
(R-HSA-6800191)
HBB [endocytic vesicle lumen]
(R-HSA-2230936)
HBB [extracellular region]
(R-HSA-2168872)
HBB [late endosome lumen]
(R-HSA-9631108)
HBB [cytosol]
(R-HSA-1008196)
HBB [lysosomal lumen]
(R-HSA-9625193)
0.527
2
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
4
UniProt:P00748 F12
11
F12 T328K (373-615) [extracellular region]
(R-HSA-9655053)
F12 T328R (373-615) [extracellular region]
(R-HSA-9655055)
F12 T328R (329-615) [extracellular region]
(R-HSA-9653243)
F12 T328K (329-615) [extracellular region]
(R-HSA-9653252)
F12 T328K(20-328) [extracellular region]
(R-HSA-9653230)
F12 T328R(20-328) [extracellular region]
(R-HSA-9653225)
F12 T328R [plasma membrane]
(R-HSA-9653226)
F12 T328K [plasma membrane]
(R-HSA-9653238)
factor XIIa heavy chain [extracellular region]
(R-HSA-158285)
factor XII [plasma membrane]
(R-HSA-158214)
factor XIIa light chain [extracellular region]
(R-HSA-158320)
0.527
3
UniProt:Q96FZ2 HMCES
0.527
3
UniProt:P57076 CF298
0.527
3
UniProt:Q7L4E1 MIGA2
1
MIGA2 [mitochondrial outer membrane]
(R-HSA-8954402)
0.527
2
UniProt:Q53H54 TRMT12
1
TRMT12 [cytoplasm]
(R-HSA-6782860)
0.527
2
UniProt:Q8IYG6 LRC56
0.527
3
UniProt:Q8TDN2 KCNV2
1
KCNV2 [plasma membrane]
(R-HSA-977505)
0.527
2
UniProt:Q9H7S9 ZNF703
1
ZNF703 [nucleoplasm]
(R-HSA-2454149)
0.527
2
UniProt:P53367 ARFP1
0.527
3
UniProt:Q8N4P2 IFT70B
2
TTC30B [ciliary tip]
(R-HSA-5637970)
TTC30B [cilium]
(R-HSA-5637971)
0.527
2
UniProt:Q8N239 KLH34
0.527
3
UniProt:Q9H6A0 DENND2D
1
DENND2D [cytosol]
(R-HSA-8876071)
0.527
2
UniProt:Q6UXT9 ABH15
0.527
3
UniProt:P31350 RRM2
1
RRM2 [cytosol]
(R-HSA-73639)
0.527
2
UniProt:Q6P158 DHX57
0.527
3
UniProt:A2VCK2 DCD2B
0.527
2
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.527
2
UniProt:Q6ZMP0 THSD4
3
THSD4 [endoplasmic reticulum lumen]
(R-HSA-5173065)
glc-fuc-THSD4 [endoplasmic reticulum lumen]
(R-HSA-5173066)
O-fuc-THSD4 [endoplasmic reticulum lumen]
(R-HSA-5173088)
0.527
2
UniProt:Q2TAL8 QRIC1
0.527
3
UniProt:Q9H6K1 ILRUN
0.527
3
UniProt:Q9NVX7 KBTB4
0.527
2
UniProt:P55039 DRG2
2
3OHK21-DRG2 [cytosol]
(R-HSA-9629595)
DRG2 [cytosol]
(R-HSA-9629597)
0.527
2
UniProt:Q9Y490 TLN1
4
TLN1 [extracellular region]
(R-HSA-350693)
TLN1(434-2541) [cytosol]
(R-HSA-9855156)
TLN1(1-433) [cytosol]
(R-HSA-9855031)
TLN1 [cytosol]
(R-HSA-350713)
0.527
2
UniProt:P61011 SRP54
1
SRP54 [cytosol]
(R-HSA-264977)
0.527
2
UniProt:Q309B1 TR16L
0.527
2
UniProt:Q96E22 NUS1
1
NUS1 [endoplasmic reticulum membrane]
(R-HSA-6806946)
0.527
3
UniProt:Q8N4N3 KLH36
0.527
2
UniProt:Q9NZV8 KCND2
1
KCND2 [plasma membrane]
(R-HSA-977453)
0.527
2
UniProt:Q38SD2 LRRK1
0.527
2
UniProt:Q2T9J0 TYSND1
4
TYSND1(111-566) [peroxisomal matrix]
(R-HSA-9033589)
TYSND1(1-110) [peroxisomal matrix]
(R-HSA-9033587)
TYSND1 [peroxisomal matrix]
(R-HSA-8933309)
TYSND1 [cytosol]
(R-HSA-9033586)
0.527
2
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.527
2
UniProt:Q9NYQ3 HAO2
2
HAO2 [cytosol]
(R-HSA-9033093)
HAO2 [peroxisomal matrix]
(R-HSA-6787806)
0.527
2
UniProt:Q6JEL2 KLH10
0.527
3
UniProt:Q96DF8 ESS2
0.527
2
UniProt:Q9NX65 ZSCAN32
1
ZSCAN32 [nucleoplasm]
(R-HSA-1247547)
0.527
2
UniProt:P56555 DSCR4
0.527
2
UniProt:Q8N831 TSYL6
0.527
2
UniProt:Q14249 NUCG
0.527
3
UniProt:Q15459 SF3A1
1
SF3A1 [nucleoplasm]
(R-HSA-71962)
0.527
3
UniProt:P69905 HBA1
4
CO-H+-HBA1 [cytosol]
(R-HSA-1237026)
HBA1 [cytosol]
(R-HSA-1008268)
HBA1 [endocytic vesicle lumen]
(R-HSA-2230966)
HBA1 [extracellular region]
(R-HSA-2168862)
0.527
2
UniProt:Q9UJ71 CD207
3
CD207 [plasma membrane]
(R-HSA-1216519)
CD207 [clathrin-coated endocytic vesicle membrane]
(R-HSA-1236762)
CD207 [early endosome membrane]
(R-HSA-1236852)
0.527
2
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.527
2
UniProt:Q99742 NPAS1
0.527
3
UniProt:Q9H0B6 KLC2
1
KLC2 [cytosol]
(R-HSA-983191)
0.527
2
UniProt:P63092 GNAS
1
GNAS2 [plasma membrane]
(R-HSA-164387)
0.527
2
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.527
2
UniProt:Q9Y5Z7 HCFC2
1
HCFC2 [nucleoplasm]
(R-HSA-9821232)
0.527
3
UniProt:P22612 PRKACG
3
PRKACG [ciliary base]
(R-HSA-5610405)
PRKACG [cytosol]
(R-HSA-57848)
PRKACG [nucleoplasm]
(R-HSA-111938)
0.527
2
UniProt:Q12874 SF3A3
1
SF3A3 [nucleoplasm]
(R-HSA-71966)
0.527
2
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.527
3
UniProt:P27540 ARNT
1
ARNT [nucleoplasm]
(R-HSA-1234098)
0.527
2
UniProt:A6NED2 RCCD1
2
3OHR141-RCCD1 [cytosol]
(R-HSA-9629871)
RCCD1 [cytosol]
(R-HSA-9629873)
0.527
2
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.527
2
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.527
2
UniProt:Q8WXB1 METTL21A
1
METTL21A [nucleoplasm]
(R-HSA-8876682)
0.527
3
UniProt:Q9UNU6 CYP8B1
1
CYP8B1 [endoplasmic reticulum membrane]
(R-HSA-192012)
0.527
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
3
UniProt:Q96SI1 KCTD15
1
KCTD15 [nucleoplasm]
(R-HSA-8864337)
0.527
2
UniProt:Q15813 TBCE
1
TBCE [cytosol]
(R-HSA-379539)
0.527
2
UniProt:Q12948 FOXC1
1
FOXC1 [nucleoplasm]
(R-HSA-3927815)
0.527
2
UniProt:P02768 ALB
7
ALB(19-609) [extracellular region]
(R-HSA-114609)
ALB [platelet alpha granule lumen]
(R-HSA-49865)
salicyl-ALB [extracellular region]
(R-HSA-9750694)
acetyl-ALB [extracellular region]
(R-HSA-9749660)
ALB [extracellular region]
(R-HSA-194115)
p-ALB [endoplasmic reticulum lumen]
(R-HSA-8956930)
ALB [endoplasmic reticulum lumen]
(R-HSA-8956690)
0.527
2
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.527
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.527
3
UniProt:Q9Y6A5 TACC3
1
TACC3 [cytosol]
(R-HSA-2160956)
0.527
2
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.527
3
UniProt:Q7Z6Z6 PNPLA5
1
PNPLA5 [cytosol]
(R-HSA-8848346)
0.527
3
UniProt:Q6NZI2 PTRF
2
PTRF [nucleoplasm]
(R-HSA-74981)
CAVIN1 [plasma membrane]
(R-HSA-9714278)
0.527
2
UniProt:P03485 M
6
M1 [plasma membrane]
(R-FLU-195782)
M1 [extracellular region]
(R-FLU-169241)
M1 [endocytic vesicle membrane]
(R-FLU-189168)
M1 [endosome lumen]
(R-FLU-189155)
M1 [cytosol]
(R-FLU-169073)
M1 [nucleoplasm]
(R-FLU-186959)
0.524
4
UniProt:Q9NQ11 ATP13A2
1
ATP13A2 [lysosomal lumen]
(R-HSA-939762)
0.508
2
UniProt:Q8AZK7 EBNA5
0.499
3
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.499
2
UniProt:P14598 NCF1
4
NCF1 [cytosol]
(R-HSA-1222296)
p-6S-NCF1 [phagolysosome]
(R-HSA-1996220)
p-S345-NCF1 [cytosol]
(R-HSA-9626824)
p-6S-NCF1 [cytosol]
(R-HSA-9626854)
0.499
2
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
4
UniProt:Q15131 CDK10
0.499
2
UniProt:Q9GZX7 AICDA
1
AICDA [nucleoplasm]
(R-HSA-452477)
0.499
2
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.499
4
UniProt:P61764 STXBP1
2
STXBP1 [cytosol]
(R-HSA-6794256)
STXBP1 [plasma membrane]
(R-HSA-2980862)
0.499
2
UniProt:Q99IB8-PRO_0000045599
0.488
2
UniProt:O15013 ARHGEF10
1
ARHGEF10 [cytosol]
(R-HSA-8873917)
0.483
3
UniProt:Q9H9T3 ELP3
1
ELP3 [nucleoplasm]
(R-HSA-3318364)
0.483
2
UniProt:O75190 DNAJB6
2
DNAJB6 [cytosol]
(R-HSA-5252014)
DNAJB6 [nucleoplasm]
(R-HSA-5255425)
0.482
2
UniProt:O95801 TTC4
0.482
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text