Reactome | EXOC4 [plasma membrane]

EXOC4 [plasma membrane]

Stable Identifier

R-HSA-264989

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96A65 EXOC4

Gene Names

EXOC4, KIAA1699, SEC8, SEC8L1

Chain

initiator methionine:, chain:2-974

Reference Genes

BioGPS Gene:60412 Q96A652

COSMIC (genes):EXOC4 EXOC4

CTD Gene:60412 Q96A652

dbSNP Gene:60412 Q96A652

ENSEMBL:ENSG00000131558 EXOC4

HGNC:30389 Q96A652

KEGG:hsa:60412 Q96A652

Monarch:60412 Q96A652

NCBI Gene:60412 Q96A652

OMIM:608185 Q96A652

UCSC:Q96A65 Q96A652

Reference Transcript

RefSeq:NM_021807.3 Q96A652

Participates

as a component of

Exocyst Complex [plasma membrane] (Homo sapiens)

as an input of

Exocyst complex formation (Homo sapiens)

Other forms of this molecule

EXOC4 [cytosol]

Inferred To

Sec8 [plasma membrane] (Drosophila melanogaster)

exoc4 [plasma membrane] (Dictyostelium discoideum)

exoc4 [plasma membrane] (Xenopus tropicalis)

EXOC4 [plasma membrane] (Bos taurus)

EXOC4 [plasma membrane] (Canis familiaris)

EXOC4 [plasma membrane] (Gallus gallus)

Exoc4 [plasma membrane] (Mus musculus)

Exoc4 [plasma membrane] (Rattus norvegicus)

SEC8 [plasma membrane] (Saccharomyces cerevisiae)

sec-8 [plasma membrane] (Caenorhabditis elegans)

sec8 [plasma membrane] (Schizosaccharomyces pombe)

Cross References

OpenTargets

ENSG00000131558

ENSEMBL

ENST00000393161, ENSP00000253861, ENST00000253861, ENSP00000376868, ENSG00000131558

HPA

ENSG00000131558-EXOC4

GeneCards

EXOC4

PRO

Q96A65

Pharos - Targets

Q96A65

GlyGen

Q96A65

PDB

7PC5

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NV70 EXOC1	2	EXOC1 [plasma membrane] (R-HSA-2872284) EXOC1 [cytosol] (R-HSA-5623375)	0.852	7
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.789	8
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.789	7
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.725	6
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.725	5
UniProt:Q96KP1 EXOC2	2	EXOC2 [cytosol] (R-HSA-5623376) EXOC2 [plasma membrane] (R-HSA-264887)	0.638	4
UniProt:Q9Y2D4 EXC6B			0.638	5
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.638	4
UniProt:Q9H5N1 RABE2			0.638	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	6
UniProt:O70172	2	Pip4k2a [nucleoplasm] (R-MMU-6811484) Pip4k2a [cytosol] (R-MMU-1604641)	0.558	3
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.556	3
UniProt:Q9NR09 BIRC6	2	BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713451) BIRC6(1-958)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713450)	0.556	3
UniProt:Q96EV8 DTNBP1	1	DTNBP1 [cytosol] (R-HSA-429819)	0.547	2
UniProt:P27930 IL1R2	1	IL1R2 [plasma membrane] (R-HSA-197598)	0.527	4
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:O75558 STX11			0.527	2
UniProt:Q9UJY5 GGA1	2	GGA1 [endosome membrane] (R-HSA-5692930) GGA1 [early endosome membrane] (R-HSA-8854136)	0.527	3
UniProt:Q86VI4 LAP4B			0.524	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.508	3
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.508	2
UniProt:Q15051 IQCB1	1	IQCB1 [cytosol] (R-HSA-5626648)	0.508	2
UniProt:Q9UID3 VPS51	1	VPS51 [trans-Golgi network membrane] (R-HSA-6811027)	0.508	2
UniProt:Q53HC9 EIPR1			0.508	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.499	2
UniProt:P04601 nef	3	nef [cytosol] (R-HIV-165575) myristoylated Nef Protein (UniProt:P04601) [extracellular region] (R-HIV-3597665) myristoylated nef [cytosol] (R-HIV-167605)	0.462	2

Cite Us!