Reactome | EXOC4 [plasma membrane]

EXOC4 [plasma membrane]

Stable Identifier

R-HSA-264989

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser for interactor UniProt:P27930 IL1R2

Expand all

External Reference Information

External Reference

UniProt:Q96A65 EXOC4

Gene Names

EXOC4, KIAA1699, SEC8, SEC8L1

Chain

initiator methionine:, chain:2-974

Reference Genes

BioGPS Gene:60412 EXOC4

COSMIC (genes):EXOC4 EXOC4

CTD Gene:60412 EXOC4

dbSNP Gene:60412 EXOC4

ENSEMBL:ENSG00000131558 EXOC4

ENSEMBL_homo_sapiens_GENE:ENSG00000131558.15 EXOC4

HGNC:30389 EXOC4

KEGG Gene (Homo sapiens):60412 EXOC4

Monarch:60412 EXOC4

NCBI Gene:60412 EXOC4

OMIM:608185 EXOC4

UCSC:Q96A65 EXOC4

Reference Transcript

RefSeq:NM_021807.3 EXOC4

Other Identifiers

11718791_s_at

11718792_a_at

11733715_a_at

11733716_x_at

17051745

224926_PM_at

224926_at

240528_3p_s_at

240528_PM_s_at

240528_s_at

3025006

3025007

3025011

3025012

3025017

3025024

3025025

3025028

3025029

3025030

3025056

3025057

3025061

3025062

3025090

3025127

3025128

3025137

3025138

3025151

3025154

3025155

3025176

3025177

3025178

3025179

3025212

3025213

3025214

3025215

3025216

3025217

3025218

48072_at

48073_g_at

60412

72841_at

8136293

91389_at

A_14_P111352

A_14_P124224

A_14_P202004

A_24_P7946

GE62357

GO:0000145

GO:0000278

GO:0000281

GO:0000910

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005902

GO:0006887

GO:0006893

GO:0006904

GO:0006914

GO:0007268

GO:0015031

GO:0016020

GO:0016192

GO:0016241

GO:0023052

GO:0030165

GO:0032584

GO:0035748

GO:0042995

GO:0043005

GO:0043226

GO:0045202

GO:0048341

GO:0048856

GO:0061024

GO:0090148

GO:0090522

GO:0090543

HMNXSV003046686

HMNXSV003058107

Hs.107394.0.S1_3p_at

Hs.223829.0.A1_3p_at

Hs.223829.0.A1_3p_s_at

ILMN_1742827

ILMN_2394750

PH_hs_0026072

Participates

as a component of

Exocyst Complex [plasma membrane] (Homo sapiens)

as an input of

Exocyst complex formation (Homo sapiens)

Other forms of this molecule

EXOC4 [cytosol]

Inferred To

Sec8 [plasma membrane] (Drosophila melanogaster)

exoc4 [plasma membrane] (Dictyostelium discoideum)

exoc4 [plasma membrane] (Xenopus tropicalis)

EXOC4 [plasma membrane] (Bos taurus)

EXOC4 [plasma membrane] (Canis familiaris)

EXOC4 [plasma membrane] (Gallus gallus)

Exoc4 [plasma membrane] (Mus musculus)

Exoc4 [plasma membrane] (Rattus norvegicus)

SEC8 [plasma membrane] (Saccharomyces cerevisiae)

sec-8 [plasma membrane] (Caenorhabditis elegans)

sec8 [plasma membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_068579.3

OpenTargets

ENSG00000131558

GeneCards

Q96A65

HPA

ENSG00000131558-EXOC4

Ensembl

ENST00000393161, ENSG00000131558, ENSP00000376868, ENST00000253861, ENSP00000253861

PRO

Q96A65

Pharos - Targets

Q96A65

PDB

7PC5

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NV70 EXOC1	2	EXOC1 [plasma membrane] (R-HSA-2872284) EXOC1 [cytosol] (R-HSA-5623375)	0.852	7
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.789	7
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.789	8
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.725	6
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.725	5
UniProt:Q9Y2D4 EXC6B			0.638	5
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.638	4
UniProt:Q9H5N1 RABE2			0.638	3
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.638	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	6
UniProt:O70172	2	Pip4k2a [nucleoplasm] (R-MMU-6811484) Pip4k2a [cytosol] (R-MMU-1604641)	0.558	3
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.556	3
UniProt:Q9NR09 BIRC6	2	BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713451) BIRC6(1-958)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713450)	0.556	3
UniProt:Q96EV8 DTNBP1	1	DTNBP1 [cytosol] (R-HSA-429819)	0.547	2
UniProt:P27930 IL1R2	1	IL1R2 [plasma membrane] (R-HSA-197598)	0.527	4
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:O75558 STX11			0.527	2
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.527	3
UniProt:Q86VI4 LAP4B			0.524	2
UniProt:Q53HC9 EIPR1			0.508	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.508	3
UniProt:Q9UID3 VPS51	1	VPS51 [trans-Golgi network membrane] (R-HSA-6811027)	0.508	2
UniProt:Q15051 IQCB1	1	IQCB1 [cytosol] (R-HSA-5626648)	0.508	2
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.508	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.499	2
UniProt:P04601 nef	3	nef [cytosol] (R-HIV-165575) myristoylated Nef Protein (UniProt:P04601) [extracellular region] (R-HIV-3597665) myristoylated nef [cytosol] (R-HIV-167605)	0.462	2

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