Reactome | EXOC6 [plasma membrane]

EXOC6 [plasma membrane]

Stable Identifier

R-HSA-265041

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser for interactor UniProt:P27930 IL1R2

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External Reference Information

External Reference

UniProt:Q8TAG9 EXOC6

Gene Names

EXOC6, SEC15A, SEC15L, SEC15L1

Chain

chain:1-804

Reference Genes

BioGPS Gene:54536 EXOC6

COSMIC (genes):EXOC6 EXOC6

CTD Gene:54536 EXOC6

dbSNP Gene:54536 EXOC6

ENSEMBL:ENSG00000138190 EXOC6

ENSEMBL_homo_sapiens_GENE:ENSG00000138190.17 EXOC6

HGNC:23196 EXOC6

KEGG Gene (Homo sapiens):54536 EXOC6

Monarch:54536 EXOC6

NCBI Gene:54536 EXOC6

OMIM:609672 EXOC6

UCSC:Q8TAG9 EXOC6

Reference Transcript

Other Identifiers

11723221_a_at

11755493_a_at

16707503

226259_PM_at

226259_at

233924_PM_s_at

233924_s_at

3258257

3258261

3258262

3258271

3258283

3258284

3258285

3258286

3258288

3258290

3258292

3258295

3258298

3258301

3258302

3258303

3258304

3258306

3258307

3258308

3258309

3258311

3258318

3258319

3258320

3258328

3258338

3258341

3258342

3258355

3258356

49287_at

54536

59310_at

7929288

A_14_P139287

A_23_P169576

A_32_P58280

GE56714

GO:0000145

GO:0000278

GO:0000281

GO:0000910

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006886

GO:0006887

GO:0006893

GO:0006904

GO:0015031

GO:0016192

GO:0030426

GO:0042995

GO:0048471

GO:0061024

GO:0090148

GO:0090522

GO:0090543

HMNXSV003000060

HMNXSV003056933

Hs.110454.0.S1_3p_at

Hs.110454.1.S1_3p_a_at

ILMN_1651628

ILMN_1667686

ILMN_1679687

PH_hs_0023364

TC10000661.hg

Participates

as a component of

Exocyst Complex [plasma membrane] (Homo sapiens)

as an input of

Exocyst complex formation (Homo sapiens)

Other forms of this molecule

EXOC6 [cytosol]

Inferred To

Sec15 [plasma membrane] (Drosophila melanogaster)

EXOC6 [plasma membrane] (Bos taurus)

EXOC6 [plasma membrane] (Canis familiaris)

EXOC6 [plasma membrane] (Gallus gallus)

Exoc6 [plasma membrane] (Mus musculus)

Exoc6 [plasma membrane] (Rattus norvegicus)

sec-15 [plasma membrane] (Caenorhabditis elegans)

SEC15 [plasma membrane] (Saccharomyces cerevisiae)

sec15 [plasma membrane] (Schizosaccharomyces pombe)

exoc6 [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001306124.1, NP_001306129.1, NP_001013870.1, NP_001306123.1, XP_016871834.1, NP_061926.3

OpenTargets

ENSG00000138190

HPA

ENSG00000138190-EXOC6

GeneCards

Q8TAG9

Ensembl

ENST00000672817, ENSG00000138190, ENST00000371552, ENSP00000500529, ENSP00000360607, ENSP00000500468, ENST00000260762, ENSP00000260762, ENST00000671701

PRO

Q8TAG9

Pharos - Targets

Q8TAG9

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.841	9
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.789	7
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.725	6
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.725	5
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.638	4
UniProt:Q9NV70 EXOC1	2	EXOC1 [plasma membrane] (R-HSA-2872284) EXOC1 [cytosol] (R-HSA-5623375)	0.638	4
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.638	5
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:Q9H410 DSN1	3	DSN1 [cytosol] (R-HSA-375308) DSN1 [azurophil granule lumen] (R-HSA-6799218) DSN1 [extracellular region] (R-HSA-6806228)	0.527	3
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	2
UniProt:O75558 STX11			0.527	2
UniProt:P49146 NPY2R	1	NPY2R [plasma membrane] (R-HSA-388905)	0.527	2
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:P62834 RAP1A	4	RAP1A [plasma membrane] (R-HSA-354118) RAP1A [endosome membrane] (R-HSA-190053) RAP1A [cytosol] (R-HSA-169884) RAP1A [specific granule membrane] (R-HSA-6806137)	0.527	2
UniProt:Q5VIR6 VPS53	1	VPS53 [trans-Golgi network membrane] (R-HSA-6811031)	0.527	2
UniProt:P27930 IL1R2	1	IL1R2 [plasma membrane] (R-HSA-197598)	0.527	4
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:P61006 RAB8A	6	GGC-RAB8A [cytoplasmic vesicle membrane] (R-HSA-1445093) RAB8A [recycling endosome membrane] (R-HSA-8854145) GGC-RAB8A [trans-Golgi network membrane] (R-HSA-8876082) GGC-RAB8A [cytosol] (R-HSA-8874063) RAB8A [Golgi membrane] (R-HSA-2562535) RAB8A [cytosol] (R-HSA-5623399)	0.508	2
UniProt:Q9Y2D4 EXC6B			0.508	2
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.508	2
UniProt:P0DTD1-PRO_0000449633 REP			0.488	2

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