Reactome | Prostaglandin E synthase isomerizes PGH2 to PGE2

Prostaglandin E synthase isomerizes PGH2 to PGE2

Stable Identifier

R-HSA-265295

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Prostaglandin E synthase isomerizes PGH2 to PGE2

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Prostaglandin E2 (PGE2) is the most abundant prostanoid in the body and is a major mediator of inflammation in diseases such as osteoarthritis and rheumatoid arthritis. The product of arachidonic acid, prostaglandin H2 (PGH2) serves as the substrate for the isomerization to PGE2. The conversion is carried out by prostaglandin E synthases. Of the three forms, two are predominanly cytosolic. Prostaglandin E synthase 3 (PTGES3) is also called cytosolic prostaglandin E2 synthase (cPGES). Prostaglandin E synthase 2 (mPGES-2, PTGES2) is synthesized as a Golgi membrane-associated protein which undergoes a spontaneous cleavage of the N-terminal hydrophobic domain leading to a truncated mature cytosolic protein.

Literature References

PubMed ID	Title	Journal	Year
10922363	Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis Tanioka, T, Murakami, M, Kudo, I, Nakatani, Y, Semmyo, N	J Biol Chem	2000
12835322	Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2 Nakashima, K, Kamei, D, Ishii, T, Watanabe, K, Masuda, S, Murakami, M, Kudo, I, Ohmiya, Y, Ishikawa, Y	J. Biol. Chem.	2003