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spherical HDL [extracellular region]
Stable Identifier
R-HSA-265523
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
spherical high-density lipoprotein, mature high-density lipoprotein
GO Cellular Component
spherical high-density lipoprotein particle
(0034366)
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Heme signaling (Homo sapiens)
FeHM oxidises LDL,HDL (Homo sapiens)
LDL,HDL [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
Nascent CMs transform into mature CMs (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
Nascent CMs transform into mature CMs (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein assembly (Homo sapiens)
Chylomicron assembly (Homo sapiens)
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
HDL clearance (Homo sapiens)
HDLBP binds HDL (Homo sapiens)
HDLBP:HDL [plasma membrane] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL and SR-BI receptor form a complex at the cell surface (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Plasma lipoprotein remodeling (Homo sapiens)
Chylomicron remodeling (Homo sapiens)
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
HDL remodeling (Homo sapiens)
CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Homo sapiens)
CETP:spherical HDL:torcetrapib complex [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL:triacylglycerol complex [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Homo sapiens)
LCAT:spherical HDL complex [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
LCAT:spherical HDL complex <=> LCAT + spherical HDL (Homo sapiens)
LCAT:spherical HDL complex [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Spherical HDL binds C and E apolipoproteins (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Spherical HDL binds membrane-associated free cholesterol and phospholipids (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging by Class B Receptors (Homo sapiens)
Platelet glycoprotein IV (CD36) binds ligands (Homo sapiens)
Ligands of CD36 [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Platelet glycoprotein IV:Ligand [plasma membrane] (Homo sapiens)
Ligands of CD36 [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Homo sapiens)
Platelet glycoprotein IV:Ligand [plasma membrane] (Homo sapiens)
Ligands of CD36 [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
SCARB1 (SR-BI, CLA-1) binds ligands (Homo sapiens)
Ligands of SCARB1 [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
SCARB1:Ligand [plasma membrane] (Homo sapiens)
Ligands of SCARB1 [extracellular region] (Homo sapiens)
spherical HDL [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16968945
Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
Chapman, MJ
,
Kontush, A
Pharmacol Rev
2006
Participants
components
x 4
APOA1(25-266) [extracellular region]
(Homo sapiens)
x 160
CHEST [extracellular region]
x 40
CHOL [extracellular region]
x 140
PL [extracellular region]
x 20
TAGs [extracellular region]
Participates
as an output of
Nascent CMs transform into mature CMs (Homo sapiens)
LCAT:spherical HDL complex <=> LCAT + spherical HDL (Homo sapiens)
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron (Homo sapiens)
as a component of
HDLBP:HDL [plasma membrane] (Homo sapiens)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Homo sapiens)
CETP:spherical HDL:torcetrapib complex [extracellular region] (Homo sapiens)
LCAT:spherical HDL complex [extracellular region] (Homo sapiens)
spherical HDL:triacylglycerol complex [extracellular region] (Homo sapiens)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Homo sapiens)
as an input of
HDLBP binds HDL (Homo sapiens)
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Homo sapiens)
Spherical HDL binds membrane-associated free cholesterol and phospholipids (Homo sapiens)
Spherical HDL binds C and E apolipoproteins (Homo sapiens)
CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Homo sapiens)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Homo sapiens)
CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Homo sapiens)
spherical HDL and SR-BI receptor form a complex at the cell surface (Homo sapiens)
as a member of
Ligands of SCARB1 [extracellular region] (Homo sapiens)
Ligands of CD36 [extracellular region] (Homo sapiens)
as a candidate of
LDL,HDL [extracellular region] (Homo sapiens)
Inferred To
spherical HDL [extracellular region]
(Bos taurus)
spherical HDL [extracellular region]
(Canis familiaris)
spherical HDL [extracellular region]
(Danio rerio)
spherical HDL [extracellular region]
(Gallus gallus)
spherical HDL [extracellular region]
(Mus musculus)
spherical HDL [extracellular region]
(Rattus norvegicus)
spherical HDL [extracellular region]
(Sus scrofa)
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