Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
LTC4S [nuclear envelope]
Stable Identifier
R-HSA-266025
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
Leukotriene C4 synthase, LTC4S_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of Lipoxins (LX) (Homo sapiens)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
ALOX5 oxidises 15S-HpETE to LXA4/B4 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
Arachidonate is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
ALOX5 binds ALOX5 inhibitors (Homo sapiens)
ALOX5:ALOX5 inhibitors [nuclear envelope] (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
Arachidonate is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
EXA4 is converted to EXC4 by LTC4S (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
LTA4 is converted to LTC4 by LTC4S (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16873 LTC4S
Gene Names
LTC4S
Chain
chain:1-150
Reference Genes
BioGPS Gene:4056 LTC4S
COSMIC (genes):LTC4S LTC4S
CTD Gene:4056 LTC4S
dbSNP Gene:4056 LTC4S
ENSEMBL:ENSG00000213316 LTC4S
HGNC:6719 LTC4S
KEGG:hsa:4056 LTC4S
Monarch:4056 LTC4S
NCBI Gene:4056 LTC4S
OMIM:246530 LTC4S
UCSC:Q16873 LTC4S
Reference Transcript
RefSeq:NM_145867.1 LTC4S
Other Identifiers
11729075_s_at
11729076_x_at
16993451
206480_PM_at
206480_at
2844462
2844463
2844465
2844466
2844467
2844468
2844469
2844470
2844471
2844472
2844473
2844474
2844475
2844476
2844478
39968_at
4056
8110546
8110562
A_14_P130111
A_24_P397294
A_33_P3220149
GE80456
GO:0003824
GO:0004364
GO:0004464
GO:0004602
GO:0005515
GO:0005634
GO:0005635
GO:0005640
GO:0005783
GO:0005789
GO:0006629
GO:0006691
GO:0008047
GO:0008289
GO:0016020
GO:0016209
GO:0016491
GO:0016740
GO:0016829
GO:0019370
GO:0031965
GO:0042759
GO:0042802
GO:0043226
GO:0043231
GO:0098754
GO:0098772
GO:0098869
HMNXSV003016769
HMNXSV003023196
ILMN_1668247
ILMN_1813335
TC05003417.hg
U50136_rna1_at
g4505040_3p_at
Participates
as a component of
LTC4S trimer [nuclear envelope] (Homo sapiens)
Other forms of this molecule
LTC4S [endoplasmic reticulum membrane]
Inferred To
ltc4s [nuclear envelope]
(Xenopus tropicalis)
ltc4s.2 [nuclear envelope]
(Xenopus tropicalis)
mgst [nuclear envelope]
(Dictyostelium discoideum)
Homologues of LTC4S [nuclear envelope]
(Xenopus tropicalis)
LTC4S [nuclear envelope]
(Bos taurus)
LTC4S [nuclear envelope]
(Canis familiaris)
LTC4S [nuclear envelope]
(Gallus gallus)
LTC4S [nuclear envelope]
(Mus musculus)
LTC4S [nuclear envelope]
(Rattus norvegicus)
LTC4S [nuclear envelope]
(Sus scrofa)
Cross References
RefSeq
NP_665874.1
Guide to Pharmacology - Targets
1391
ENSEMBL
ENST00000292596
,
ENSP00000492334
,
ENST00000639087
,
ENSP00000292596
OpenTargets
ENSG00000213316
HPA
ENSG00000213316-LTC4S
ZINC - Substances
LTC4S_HUMAN
ZINC target
Q16873
PRO
Q16873
Pharos - Targets
Q16873
HMDB Protein
HMDBP00807
PDB
3LEO
,
6R7D
,
4JC7
,
3PCV
,
4WAB
,
4JCZ
,
3HKK
,
4J7T
,
4BPM
,
4J7Y
,
3B29
,
2UUH
,
2PNO
,
2UUI
,
4JRZ
,
5HV9
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
5
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:O14843 FFAR3
1
FFAR3 [plasma membrane]
(R-HSA-443951)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text