LTA4 is converted to LTC4 by LTC4S

Stable Identifier
R-HSA-266050
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
LTA4 conjugates with glutathione to form LTC4
ReviewStatus
5/5
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Leukotriene A4 conjugates with reduced glutathione (GSH) to produce leukotriene C4 (LTC4). This conjugation is mediated by the homodimeric, perinuclear membrane-bound enzyme leukotriene C4 synthase (LTC4S) (Lam et al. 1994, Welsch et al. 1994). LTC4S differs from cytosolic and microsomal GSH-S-transferases by having a very narrow substrate specificity and the inability to conjugate xenobiotics.
Literature References
PubMed ID Title Journal Year
7937884 Molecular cloning and expression of human leukotriene-C4 synthase

Hauser, SD, Isakson, PC, Mathis, KJ, Welsch, DJ, Creely, DP, Krivi, GG

Proc Natl Acad Sci U S A 1994
8052639 Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4

Freeman, GJ, Lam, BK, Austen, KF, Penrose, JF

Proc Natl Acad Sci U S A 1994
Participants
Participates
Catalyst Activity

leukotriene-C4 synthase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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