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ABCC1 [plasma membrane]
Stable Identifier
R-HSA-266068
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Multidrug resistance-associated protein 1, MRP1
Icon
Locations in the PathwayBrowser for interactor UniProt:A0A0F6B5H5 A0A0F6B5H5
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
ABCC1 transports BIL from cytosol to extracellular region (blood) (Homo sapiens)
ABCC1 [plasma membrane] (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating MDR associated enzymes (Homo sapiens)
NFE2L2 dependent ABCC1 expression (Homo sapiens)
ABCC1 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
LTC4 is exported from the cytosol by ABCC1 (Homo sapiens)
ABCC1 [plasma membrane] (Homo sapiens)
Metabolism of porphyrins (Homo sapiens)
Heme degradation (Homo sapiens)
ABCC1 transports BIL from cytosol to extracellular region (blood) (Homo sapiens)
ABCC1 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Transport of RCbl within the body (Homo sapiens)
ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)
ABCC1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P33527 ABCC1
Gene Names
ABCC1, MRP, MRP1
Chain
chain:1-1531
Reference Genes
BioGPS Gene:4363 ABCC1
COSMIC (genes):ABCC1 ABCC1
CTD Gene:4363 ABCC1
dbSNP Gene:4363 ABCC1
ENSEMBL:ENSG00000103222 ABCC1
ENSEMBL:ENSG00000103222.20 ABCC1
ENSEMBL:ENSG00000278183.4 ABCC1
HGNC:51 ABCC1
KEGG Gene (Homo sapiens):4363 ABCC1
Monarch:4363 ABCC1
NCBI Gene:4363 ABCC1
OMIM:158343 ABCC1
UCSC:P33527 ABCC1
Reference Transcript
RefSeq:NM_004996.3 ABCC1
Other Identifiers
11719420_a_at
11719421_a_at
11719422_s_at
16816214
1896_s_at
202804_PM_at
202804_at
202805_PM_s_at
202805_s_at
34016_s_at
34017_s_at
34384_at
3649891
3649892
3649902
3649903
3649904
3649905
3649909
3649911
3649912
3649913
3649914
3649918
3649921
3649924
3649928
3649931
3649933
3649934
3649935
3649936
3649937
3649942
3649945
3649947
3649948
3649950
3649954
3649955
3649958
3649960
3649962
3649963
3649965
3649966
4363
7993478
A_24_P227831
GE60036
GO:0000166
GO:0003013
GO:0003824
GO:0005215
GO:0005524
GO:0005576
GO:0005615
GO:0005886
GO:0006691
GO:0006805
GO:0006869
GO:0006954
GO:0008559
GO:0009410
GO:0009925
GO:0015420
GO:0015431
GO:0015562
GO:0015889
GO:0016020
GO:0016323
GO:0016324
GO:0016328
GO:0016787
GO:0016887
GO:0022857
GO:0034040
GO:0034599
GO:0034634
GO:0034775
GO:0042167
GO:0042626
GO:0042908
GO:0042910
GO:0043225
GO:0043226
GO:0045332
GO:0046943
GO:0048870
GO:0050729
GO:0055085
GO:0060326
GO:0061024
GO:0070062
GO:0070633
GO:0070729
GO:0071716
GO:0098656
GO:0099039
GO:0140115
GO:0140359
GO:0140657
GO:0150104
GO:1904646
GO:1905039
GO:1990962
HMNXSV003013255
Hs.89433.4.S3_3p_at
ILMN_1802404
ILMN_2335302
L05628_s_at
PH_hs_0024545
TC16000193.hg
X78338_at
g9955961_3p_a_at
Participates
as a member of
ABCC1,4,5 [plasma membrane] (Homo sapiens)
ABCCs [plasma membrane] (Homo sapiens)
as an output of
NFE2L2 dependent ABCC1 expression (Homo sapiens)
Inferred To
abcc1 [plasma membrane]
(Xenopus tropicalis)
mrp-1 [plasma membrane]
(Caenorhabditis elegans)
MRP [plasma membrane]
(Drosophila melanogaster)
ABCC1 [plasma membrane]
(Bos taurus)
ABCC1 [plasma membrane]
(Canis familiaris)
ABCC1 [plasma membrane]
(Danio rerio)
ABCC1 [plasma membrane]
(Dictyostelium discoideum)
ABCC1 [plasma membrane]
(Gallus gallus)
ABCC1 [plasma membrane]
(Mus musculus)
ABCC1 [plasma membrane]
(Rattus norvegicus)
ABCC1 [plasma membrane]
(Saccharomyces cerevisiae)
ABCC1 [plasma membrane]
(Schizosaccharomyces pombe)
ABCC1 [plasma membrane]
(Sus scrofa)
Homologues of ABCC1 [plasma membrane]
(Canis familiaris)
Cross References
RefSeq
NP_004987.2
ZINC - World Drugs
MRP1_HUMAN
Guide to Pharmacology - Targets
779
OpenTargets
ENSG00000103222
ZINC - FDA approved
MRP1_HUMAN
ZINC - Substances
MRP1_HUMAN
ZINC target
P33527
ZINC - Biogenic
MRP1_HUMAN
PRO
P33527
PDB
4C3Z
,
2CBZ
ZINC - Investigational
MRP1_HUMAN
ZINC - Metabolites
MRP1_HUMAN
IntEnz
7.6.2.3
GeneCards
P33527
HPA
ENSG00000103222-ABCC1
Ensembl
ENSG00000103222
,
ENSP00000382342
,
ENST00000399410
,
ENST00000572882
,
ENST00000621144
,
ENSP00000382340
,
ENSG00000278183
,
ENSP00000461615
,
ENSP00000483316
,
ENST00000399408
Pharos - Targets
P33527
Orphanet
24316
ZINC - Predictions - Purchasable
MRP1_HUMAN
HMDB Protein
HMDBP01858
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTD3 ORF9C
0.527
2
UniProt:A0A0F6B5H5 A0A0F6B5H5
0.462
2
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