NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1

Stable Identifier
R-HSA-2666278
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) translocation mutant is susceptible to ADAM10/17-mediated cleavage in the absence of ligand binding (Ellisen et al. 1991).
Literature References
PubMed ID Title Journal Year
1831692 TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Smith, SD, Sklar, J, Ellisen, LW, Bird, J, West, DC, Soreng, AL, Reynolds, TC

Cell 1991
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]

Physical Entity
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
Activity
metallopeptidase activity (GO:0008237)
Functional status

Gain of function of NOTCH1 t(7;9)(NOTCH1:M1580 K2555) [plasma membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-11-24)
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