Viral serpin blocks caspase-8 activity

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Cowpox virus, Vaccinia virus
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SPI-2/CrmA (cytokine response modifier A) is a poxvirus gene product with homology to members of the serpin (serine protease inhibitor) superfamily. Cowpox virus-derived and vaccinia virus-derived CrmA cDNAs transfected into cells inhibit apoptosis induced by Fas-ligation and activation of TNFR1 (Tewari M and Dixit VM 1995; Miura M et al, 1995; Kettle S et al. 1997). Cowpox virus-derived CrmA was shown to selectively inhibit caspases in Fas-mediated apoptosis, showing the highest affinity for interleukin-1 beta-converting enzyme (ICE) and a similarly high affinity for caspase-8, Ki = 0.95 nM (Zhou Q et al. 1997).
Literature References
PubMed ID Title Journal Year
9065443 Target protease specificity of the viral serpin CrmA. Analysis of five caspases

Snipas, S, Zhou, Q, Muzio, M, Dixit, VM, Orth, K, Salvesen, GS

J. Biol. Chem. 1997
9049422 Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever

Khanna, A, Alcamí, A, Jassoy, C, Kettle, S, Smith, GL, Ehret, R

J. Gen. Virol. 1997
7667287 Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway

Friedlander, RM, Yuan, J, Miura, M

Proc. Natl. Acad. Sci. U.S.A. 1995
7531702 Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

Tewari, M, Dixit, VM

J. Biol. Chem. 1995
Event Information
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
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