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Syndecans 1, 2, 4, (3) bind FGF2
Stable Identifier
R-HSA-2684507
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins, including heparin-binding growth factors such as fibroblast growth factors (FGFs), mediating interaction with FGF receptors (Kiefer et al. 1990, Bernfield & Hooper 1991, Steinfeld et al. 1996, Chua et al. 2004). Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
8609172
Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican
Van den Berghe, H
,
David, G
,
Steinfeld, R
J. Cell Biol.
1996
Participants
Input
FGF2(10-155) [extracellular region]
(Homo sapiens)
SDC1, 2, 4, (3) [plasma membrane]
(Homo sapiens)
Output
SDC1,2,4,(3):FGF2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Syndecan interactions (Homo sapiens)
Orthologous Events
Syndecans 1, 2, 4, (3) bind FGF2 (Bos taurus)
Syndecans 1, 2, 4, (3) bind FGF2 (Caenorhabditis elegans)
Syndecans 1, 2, 4, (3) bind FGF2 (Canis familiaris)
Syndecans 1, 2, 4, (3) bind FGF2 (Danio rerio)
Syndecans 1, 2, 4, (3) bind FGF2 (Gallus gallus)
Syndecans 1, 2, 4, (3) bind FGF2 (Mus musculus)
Syndecans 1, 2, 4, (3) bind FGF2 (Rattus norvegicus)
Syndecans 1, 2, 4, (3) bind FGF2 (Sus scrofa)
Syndecans 1, 2, 4, (3) bind FGF2 (Xenopus tropicalis)
Authored
Jupe, S (2012-07-31)
Reviewed
Fuentes, J (2013-05-22)
Created
Jupe, S (2012-11-30)
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