TPCN1/2 transport lysosomal Ca2+ to cytosol

Stable Identifier
R-HSA-2685505
Type
Reaction [transition]
Species
Homo sapiens
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Calcium (Ca2+) can be mobilised from intracellular stores by the presence of nicotinic acid adenine dinucleotide phosphate (NAADP). Two pore calcium channel proteins 1 and 2 (TPCN1 and 2) are expressed on endosomal (not shown here) and lysosomal membranes and mediate the mobilization of Ca2+ from these organelles when activated by NAADP (Brailoiu et al. 2009, Calcraft et al. 2009).

Literature References
PubMed ID Title Journal Year
19620632 Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

Brailoiu, E, Churamani, D, Cai, X, Schrlau, MG, Brailoiu, GC, Gao, X, Hooper, R, Boulware, MJ, Dun, NJ, Marchant, JS, Patel, S

J. Cell Biol. 2009
19387438 NAADP mobilizes calcium from acidic organelles through two-pore channels

Calcraft, PJ, Ruas, M, Pan, Z, Cheng, X, Arredouani, A, Hao, X, Tang, J, Rietdorf, K, Teboul, L, Chuang, KT, Lin, P, Xiao, R, Wang, C, Zhu, Y, Lin, Y, Wyatt, CN, Parrington, J, Ma, J, Evans, AM, Galione, A, Zhu, MX

Nature 2009
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Catalyst Activity

NAADP-sensitive calcium-release channel activity of TPCN1/2 [lysosomal membrane]

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