TPCN1/2 transport lysosomal Ca2+ to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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Calcium (Ca2+) can be mobilised from intracellular stores by the presence of nicotinic acid adenine dinucleotide phosphate (NAADP). Two pore calcium channel proteins 1 and 2 (TPCN1 and 2) are expressed on endosomal (not shown here) and lysosomal membranes and mediate the mobilization of Ca2+ from these organelles when activated by NAADP (Brailoiu et al. 2009, Calcraft et al. 2009).

Literature References
PubMed ID Title Journal Year
19387438 NAADP mobilizes calcium from acidic organelles through two-pore channels

Lin, P, Galione, A, Wang, C, Arredouani, A, Hao, X, Rietdorf, K, Ruas, M, Zhu, MX, Pan, Z, Ma, J, Lin, Y, Xiao, R, Zhu, Y, Teboul, L, Tang, J, Evans, AM, Chuang, KT, Calcraft, PJ, Wyatt, CN, Parrington, J, Cheng, X

Nature 2009
19620632 Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

Patel, S, Boulware, MJ, Brailoiu, E, Dun, NJ, Brailoiu, GC, Cai, X, Marchant, JS, Hooper, R, Gao, X, Schrlau, MG, Churamani, D

J. Cell Biol. 2009
Catalyst Activity

NAADP-sensitive calcium-release channel activity of TPCN1/2 [lysosomal membrane]

This event is regulated
Positively by