Reactome | p-T1400,T1412-MAP3K1 [cytosol]

p-T1400,T1412-MAP3K1 [cytosol]

Stable Identifier

R-HSA-2685607

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T1400,T1412-MEKK1

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External Reference Information

External Reference

UniProt:Q13233 MAP3K1

Gene Names

MAP3K1, MAPKKK1, MEKK, MEKK1

Chain

initiator methionine:, chain:2-1512

Reference Genes

BioGPS Gene:4214 MAP3K1

COSMIC (genes):MAP3K1 MAP3K1

CTD Gene:4214 MAP3K1

dbSNP Gene:4214 MAP3K1

ENSEMBL:ENSG00000095015 MAP3K1

HGNC:6848 MAP3K1

KEGG:hsa:4214 MAP3K1

Monarch:4214 MAP3K1

NCBI Gene:4214 MAP3K1

OMIM:600982 MAP3K1

UCSC:Q13233 MAP3K1

Reference Transcript

RefSeq:NM_005921.1 MAP3K1

Other Identifiers

11728093_a_at

11728094_s_at

16984945

2004_at

214786_PM_at

214786_at

225927_PM_at

225927_at

2810339

2810363

2810364

2810366

2810369

2810370

2810371

2810372

2810373

2810374

2810375

2810376

2810377

2810378

2810379

2810380

2810381

2810382

2810383

2810384

2810385

2810386

2810387

2810388

2810389

2810390

2810391

2810393

2810394

33009_at

4214

65480_at

8105436

A_33_P3368139

GE54372

GE88576

GO:0000165

GO:0003824

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006468

GO:0008270

GO:0016740

GO:0019901

GO:0038095

GO:0046872

GO:0070160

GO:0071260

GO:0106310

GO:0140096

HMNXSV003043042

Hs.170610.0.A1_3p_at

Hs.298727.0.S1_3p_s_at

ILMN_1723020

PH_hs_0022816

TC05000243.hg

Participates

as an output of

Autophosphorylation and activation of MEKK1 (Homo sapiens)

Other forms of this molecule

MAP3K1 [cytosol]

Inferred To

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Bos taurus)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Dictyostelium discoideum)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Mus musculus)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Rattus norvegicus)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Sus scrofa)

phospho-p-T1400,T1412-MAP3K1 [cytosol] (Xenopus tropicalis)

Homologues of p-T1400,T1412-MAP3K1 [cytosol] (Dictyostelium discoideum)

phospho-MAP3K1 [cytosol] (Canis familiaris)

phospho-MAP3K1 [cytosol] (Gallus gallus)

Modified Residues

Name

O-phospho-L-threonine at 1400

Coordinate

1400

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 1412

Coordinate

1412

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_005912.1

ZINC - World Drugs

M3K1_HUMAN

Guide to Pharmacology - Targets

2069

ENSEMBL

ENST00000399503, ENSP00000382423

OpenTargets

ENSG00000095015

ZINC - FDA approved

M3K1_HUMAN

ZINC - Substances

M3K1_HUMAN

ZINC - Biogenic

M3K1_HUMAN

ZINC target

Q13233

PRO

Q13233

GlyGen

Q13233

PDB

6WHB

ZINC - Investigational

M3K1_HUMAN

HPA

ENSG00000095015-MAP3K1

Pharos - Targets

Q13233

Orphanet

MAP3K1

ZINC - Predictions - Purchasable

M3K1_HUMAN

HMDB Protein

HMDBP01134

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.71	4
UniProt:P61962 DCAF7	2	Unfolded DCAF7 [cytosol] (R-HSA-6813821) DCAF7 [nucleoplasm] (R-HSA-8863312)	0.709	7
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.609	2
UniProt:P45985 MAP2K4	4	MAP2K4(?-399) [cytosol] (R-HSA-5211396) MAP2K4(1-?) [cytosol] (R-HSA-5211402) p-S257,T261-MAP2K4 [cytosol] (R-HSA-168170) MAP2K4 [cytosol] (R-HSA-168107)	0.602	3
UniProt:P34931 HSPA1L	2	HSPA1L [nucleoplasm] (R-HSA-5082367) HSPA1L [cytosol] (R-HSA-3371410)	0.536	2
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.536	2
IntAct:EBI-1108795 NPM			0.499	3
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.499	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.483	2

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