Reactome | Autophosphorylation of PAK

Autophosphorylation of PAK

Stable Identifier

R-HSA-2730856

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Upon dimer disassociation PAK1 autophosphorylates in both cis- and trans- manner. Serine 144 (S144) in the GTPase-binding domain and threonine 423 (T423) in the activation loop are the target sites for autophosphorylation (Parrini et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11804587	Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 Parrini, MC, Lei, M, Mayer, BJ, Harrison, SC	Mol Cell	2002
11278486	The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity Manser, E, Lim, L, Chong, C, Tan, L	J Biol Chem	2001