Phosphorylation of MEK7 by MEKK1

Stable Identifier
Reaction [transition]
Homo sapiens
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MKK7 is activated by MEKK1 and the residues serine 271 and threonine 275 are the potential phosphorylation sites that are crucial for its kinase activity (phosphorylation sites are based on sequence alignment with MAP kinase kinase family members).

Literature References
PubMed ID Title Journal Year
11306453 Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers

Dubauskas, Z, Vander Griend, DJ, Stadler, WM, Zhan, P, Sokoloff, MH, Rubin, MA, Ichikawa, T, Ichikawa, Y, Karrison, T, Rinker-Schaeffer, CW, Benson, DA, Kim, HL, Lin, A, Chekmareva, MA, Yoshida, BA, Yang, X

Cancer Res. 2001
9639556 Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1

Dorow, DS, Cuenda, A

Biochem. J. 1998
Catalyst Activity

protein serine/threonine kinase activity of p-T1400,T1412-MAP3K1 [cytosol]

Orthologous Events
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