Phosphorylation of PIP2 to PIP3 by PI3K

Stable Identifier
R-HSA-2730870
Type
Reaction
Species
Homo sapiens
Compartment
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PI3K catalyzes the conversion of phosphatidylinositol 4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-triphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and AKT.

Literature References
PubMed ID Title Journal Year
2833705 Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

Downes, CP, Cantley, LC, Keeler, M, Whitman, M, Keller, T

Nature 1988
12660731 The role of PI3K in immune cells

Koyasu, S

Nat Immunol 2003
Participants
Participates
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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