CLCN3 exchanges Cl- for H+

Stable Identifier
R-HSA-2731002
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, late endosome lumen, late endosome membrane
ReviewStatus
5/5
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CLCN3 exchanges Cl- for H+
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The H+/Cl- exchange transporter CLCN3 (Borsani et al. 1995) mediates the exchange of endosomal Cl- for cytosolic H+ across late endosomal membranes, contributing to the acidification of endosomes. The activity of CLCN3 is inferred from experiments in mice (Stobrawa et al. 2001, Hara-Chikuma et al. 2005).

Literature References
PubMed ID Title Journal Year
11182090 Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus

Ruether, K, Zdebik, AA, Bösl, MR, Jentsch, TJ, Jahn, H, Jahn, R, Schweizer, M, Draguhn, A, Takamori, S, Stobrawa, SM, Engel, D, Breiderhoff, T

Neuron 2001
15504734 ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

Uchida, S, Hara-Chikuma, M, Yang, B, Sasaki, S, Sonawane, ND, Verkman, AS

J. Biol. Chem. 2005
7665160 Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein

Taglialatela, M, Ballabio, A, Rugarli, EI, Wong, C, Borsani, G

Genomics 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

antiporter activity of CLCN3 [late endosome membrane]

Physical Entity
CLCN3 [late endosome membrane] (Homo sapiens)
Activity
antiporter activity (GO:0015297)
Inferred From
Clcn3 exchanges Cl- for H+ (Mus musculus)
Authored
Jassal, B  (2012-12-05)
Reviewed
He, L  (2013-01-28)
Created
Jassal, B  (2012-12-05)
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