Syndecans 1, 2 & 4 bind VTN

Stable Identifier
R-HSA-2731122
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins, including vitronectin (VTN) (Wilkins-Port & McKeown-Longo 1996, Wilkins-Port et al. 2003). It is thought that syndecans often act in concert with other receptors, e.g. integrins alphavbeta3 and alphavbeta5 cooperate with syndecan-1 during adhesion to vitronectin (Beauvais et al. 2004, McQuade et al. 2006) while alpha2beta1 and alpha6beta4 integrins cooperate with syndecans during adhesion to laminin (laminin alpha-1 Hozumi et al. 2006, laminin gamma-2, Ogawa et al. 2007). This relationship between syndecans and co-receptors is not well understood (Alexopoulou et al. 2007). Syndecan-null mice have subtle phenotypes when compared with mice deficient in HS chain synthesis or modification (Echtermeyer et al. 2001, Ishiquro et al. 2001, Götte et al. 2002). GPI-anchored glypicans and matrix HSPGs such as perlecan may compensate for the absence of syndecans.
Literature References
PubMed ID Title Journal Year
14681059 Vitronectin's basic domain is a syndecan ligand which functions in trans to regulate vitronectin turnover

McKeown-Longo, PJ, Tominna-Sebald, E, Wilkins-Port, CE, Sanderson, RD

Cell Commun. Adhes. 2003
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!