TTYH2/3 transport cytosolic Cl- to extracellular region

Stable Identifier
R-HSA-2744242
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Human homologues 2 and 3 (TTYH2 and 3) mediate the efflux of Cl- from cells in response to the increase in intracellular Ca2+ levels (Suzuki & Mizuno 2004, Suzuki 2006).

Literature References
PubMed ID Title Journal Year
16219661 The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels

Suzuki, M

Exp. Physiol. 2006
15010458 A novel human Cl(-) channel family related to Drosophila flightless locus

Suzuki, M, Mizuno, A

J. Biol. Chem. 2004
Participants
Participates
Catalyst Activity

intracellular calcium activated chloride channel activity of TTYH2/3 [plasma membrane]

This event is regulated
Positively by
Regulator
Summation

All CLCAs contain a consensus cleavage motif which is recognised by an internal zincin metalloprotease domain within the N terminus. Self-proteolysis within the secretory pathway yields N- and C-terminal fragments, a step critical for CLCA activation of calcium-activated chloride channels (CaCCs) mediated through the N-terminal fragment (Yurtsever et al. 2012).

Regulator
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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