TTYH1 transports cytosolic Cl- to extracellular region

Stable Identifier
R-HSA-2744349
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Protein tweety homolog 1 (TTYH1) has 5 isoforms. Isoform 3 (Campbell et al. 2000) mediates the Ca+-independent efflux of Cl- across plasma membranes (Suzuki & Mizuno 2004, Suzuki 2006).

Literature References
PubMed ID Title Journal Year
15010458 A novel human Cl(-) channel family related to Drosophila flightless locus

Suzuki, M, Mizuno, A

J. Biol. Chem. 2004
10950931 Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins

Campbell, HD, Kamei, M, Claudianos, C, Woollatt, E, Sutherland, GR, Suzuki, Y, Hida, M, Sugano, S, Young, IG

Genomics 2000
16219661 The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels

Suzuki, M

Exp. Physiol. 2006
Participants
Participates
Catalyst Activity

chloride channel activity of TTYH1-3 [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!