NOTCH1 PEST domain mutants bind JAG2

Stable Identifier
R-HSA-2768993
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NOTCH1 PEST domain mutants bind JAG2
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NOTCH1 PEST domain mutants are expected to bind to JAG2 ligand in an identical fashion to wild-type NOTCH1 (Luo et al. 1997, Shimizu et al. 2000).
Literature References
PubMed ID Title Journal Year
11006133 Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

Shimizu, K, Hirai, H, Kumano, K, Saito, T, Chiba, S

Biochem Biophys Res Commun 2000
9315665 Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor

Hasserjian, RP, Kuo, F, Aster, JC, Sklar, J, Luo, B

Mol Cell Biol 1997
Participants
Input
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Entity On Other Cell
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as an event of
Normal reaction
NOTCH1 binds JAG2 (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST domain mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-12-11)
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