Reactome | AKRs reduce RBP2:atRAL to RBP2:atROL

AKRs reduce RBP2:atRAL to RBP2:atROL

Stable Identifier

R-HSA-2855252

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RDH11 is the best-characterised enzyme that reduces all-trans-retinal (atRAL) to all-trans-retinol (atROL). In addition, several aldo-keto reductase (AKR) enzymes from subfamilies 1B and 1C also show all-trans-retinal (atRAL) reductase activity. AKR1B10 shows high reductase activity towards atRAL (Gallego et al. 2007, Ruiz et al. 2009) whereas AKR1C1, 1C3 and 1C4 all show much lower reductase activity towards arRAL (Ruiz et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21851338	Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily Parés, X, Rovira, C, Ruiz, FX, Ardèvol, A, Porté, S, Del Río-Espínola, A, Farrés, J, Gallego, O, Moro, A	Biochem. J.	2011
19014918	Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels Parés, X, de Lera, AR, Rovira, C, Ruiz, FX, Ardèvol, A, Fita, I, Farrés, J, Domínguez, M, Alvarez, R, Gallego, O, Moro, A, Alvarez, S	Chem. Biol. Interact.	2009
18087047	Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10 Parés, X, de Lera, AR, Rovira, C, Ruiz, FX, Ardèvol, A, Fita, I, Farrés, J, Domínguez, M, Alvarez, R, Gallego, O	Proc. Natl. Acad. Sci. U.S.A.	2007