Reactome | EXOC3 [secretory granule membrane]

EXOC3 [secretory granule membrane]

Stable Identifier

R-HSA-2872286

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Locations in the PathwayBrowser for interactor UniProt:P27930 IL1R2

Expand all

External Reference Information

External Reference

UniProt:O60645 EXOC3

Gene Names

EXOC3, SEC6, SEC6L1

Chain

chain:1-745

Reference Genes

BioGPS Gene:11336 EXOC3

COSMIC (genes):EXOC3 EXOC3

CTD Gene:11336 EXOC3

dbSNP Gene:11336 EXOC3

ENSEMBL:ENSG00000180104 EXOC3

ENSEMBL_homo_sapiens_GENE:ENSG00000180104.16 EXOC3

HGNC:30378 EXOC3

KEGG Gene (Homo sapiens):11336 EXOC3

Monarch:11336 EXOC3

NCBI Gene:11336 EXOC3

OMIM:608186 EXOC3

UCSC:O60645 EXOC3

Reference Transcript

Other Identifiers

11336

11716926_a_at

212630_PM_at

212630_at

2798680

2798681

2798682

2798683

2798685

2798686

2798688

2798689

2798690

2798691

2798694

2798695

2798698

2798704

2798705

2798707

2798708

2798709

2798710

2798711

2798712

2798713

2798714

2798715

2798716

37597_s_at

8104201

A_23_P93046

GE54509

GO:0000145

GO:0000149

GO:0000278

GO:0000281

GO:0000910

GO:0005515

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006887

GO:0006904

GO:0015031

GO:0016192

GO:0030426

GO:0030496

GO:0030667

GO:0031410

GO:0042734

GO:0042995

GO:0043005

GO:0043226

GO:0045296

GO:0048471

GO:0051601

GO:0061024

GO:0090148

GO:0090522

HMNXSV003048862

Hs.8088.0.A1_3p_at

ILMN_1789419

PH_hs_0030371

PH_hs_0036049

TC05000006.hg

Participates

as a component of

Exocyst Complex [plasma membrane] (Homo sapiens)

as an input of

Exocyst complex formation (Homo sapiens)

Other forms of this molecule

EXOC3 [cytosol]

Inferred To

sec-6 [secretory granule membrane] (Caenorhabditis elegans)

exoc3 [secretory granule membrane] (Dictyostelium discoideum)

EXOC3 [secretory granule membrane] (Bos taurus)

EXOC3 [secretory granule membrane] (Canis familiaris)

EXOC3 [secretory granule membrane] (Gallus gallus)

Exoc3 [secretory granule membrane] (Mus musculus)

Exoc3 [secretory granule membrane] (Rattus norvegicus)

Sec6 [secretory granule membrane] (Drosophila melanogaster)

Cross References

RefSeq

XP_016864492.1, NP_009208.2, XP_016864493.1

OpenTargets

ENSG00000180104

HPA

ENSG00000180104-EXOC3

GeneCards

O60645

Ensembl

ENSG00000180104, ENSP00000425587, ENST00000315013, ENSP00000323377, ENST00000512944

PRO

O60645

Pharos - Targets

O60645

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.725	6
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.725	6
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.725	5
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.638	4
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.638	4
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.638	4
UniProt:Q9NV70 EXOC1	2	EXOC1 [plasma membrane] (R-HSA-2872284) EXOC1 [cytosol] (R-HSA-5623375)	0.638	5
UniProt:Q96IK5 GMCL1			0.556	3
UniProt:Q9BZL4 PP12C			0.556	3
UniProt:A1L4K1 FSD2			0.556	3
UniProt:Q96NL6 SCLT1	1	SCLT1 [cytosol] (R-HSA-5620935)	0.527	2
UniProt:P0DJD1 RGPD2			0.527	2
UniProt:Q9BQ69 MACD1			0.527	2
UniProt:Q9BQD3 KXDL1			0.527	2
UniProt:Q99666 RGPD5			0.527	2
UniProt:Q8IWJ2 GCC2	3	GCC2 [cytosol] (R-HSA-6813880) GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9713455) GCC2(1-1204)-ALK(1059-1620) fusion [cytosol] (R-HSA-9713458)	0.527	3
UniProt:Q8WXW3 PIBF1			0.527	2
UniProt:P27930 IL1R2	1	IL1R2 [plasma membrane] (R-HSA-197598)	0.527	4
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) SDC2 [Golgi lumen] (R-HSA-2054101) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643)	0.527	2
UniProt:Q15643 TRIP11	4	TRIP11 [transport vesicle] (R-HSA-8847847) TRIP11 [Golgi membrane] (R-HSA-5617602) TRIP11(2-1724)-FLT3(594-993) fusion [cytosol] (R-HSA-9703323) TRIP11(2-1724)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703304)	0.527	3
UniProt:Q9Y496 KIF3A	3	KIF3A [cilium] (R-HSA-5610394) KIF3A [cytosol] (R-HSA-984767) KIF3A [ciliary tip] (R-HSA-5625377)	0.527	3
UniProt:Q13563 PKD2	3	PKD2 [ciliary membrane] (R-HSA-5623409) PKD2 [Golgi membrane] (R-HSA-5623393) PKD2 [Golgi-associated vesicle membrane] (R-HSA-5623411)	0.527	2
UniProt:Q9H0B6 KLC2	1	KLC2 [cytosol] (R-HSA-983191)	0.527	2
UniProt:Q9Y2D4 EXC6B			0.508	3
UniProt:Q13445 TMED1			0.508	2

Cite Us!