SLC9C1 exchanges Na+ for H+

Stable Identifier
R-HSA-2872463
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, sperm flagellum
ReviewStatus
5/5
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SLC9C1 exchanges Na+ for H+
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The sperm-specific Na+/H+ exchanger SLC9C1 (aka sodium/hydrogen exchanger 10, NHE10) is localized to the flagellar membrane and is involved in pH regulation of spermatozoa required for sperm motility and fertility. The activity of human SLC9C1 is inferred from experiments using mouse Slc9c1 (Wang et al. 2003).
Literature References
PubMed ID Title Journal Year
14634667 A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility

Wang, D, Doolittle, LK, Garbers, DL, Quill, TA, King, SM

Nat. Cell Biol. 2003
Participants
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Output
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as an event of
Catalyst Activity

sodium:proton antiporter activity of SLC9C1 [ciliary membrane]

Physical Entity
SLC9C1 [ciliary membrane] (Homo sapiens)
Activity
sodium:proton antiporter activity (GO:0015385)
Inferred From
Slc9c1 exchanges Na+ for H+ (Mus musculus)
Cross References
Rhea
Authored
Jassal, B  (2012-12-21)
Reviewed
He, L  (2013-01-28)
Created
Jassal, B  (2012-12-21)
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