Reactome | SLC9B2 exchanges Na+ for H+

SLC9B2 exchanges Na+ for H+

Stable Identifier

R-HSA-2889070

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space, mitochondrial inner membrane, mitochondrial matrix

Synonyms

H(+)(in) + Na(+)(out) => H(+)(out) + Na(+)(in)

ReviewStatus

5/5

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The widely expressed mitochondrial sodium/hydrogen exchanger 9B2 (SLC9B2, aka NHA2) mediates the exchange of Na+ for H+ across the inner mitochondrial membrane. (SLC9B2 also mediates Li+/H+ exchange, annotated as a separate reaction.) This transport is thought to play a role in salt homeostasis and pH regulation in humans (Fuster et al. 2008; Xiang et al. 2007).

The close similarity between SLC9B2 protein and NhaA, its E. coli ortholog, which mediates electrogenic transport of these ions (Taglicht et al. 1993), suggested that SLC9B2 transport might likewise be electrogenic (Xiang et al. 2007). Later work, however, indicates that SLC9B2 mediates the exchange of a single metal ion for a single proton (Uzdavinys et al. 2017).

Mass spectroscopic studies suggest that SLC9B2 exists as a homodimer (Landreh et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
28154142	Dissecting the proton transport pathway in electrogenic Na⁺/H⁺ antiporters Winkelmann, I, Ndi, M, Nji, E, von Ballmoos, C, Drew, D, Coinçon, M, Uzdavinys, P	Proc Natl Acad Sci U S A	2017
28071645	Integrating mass spectrometry with MD simulations reveals the role of lipids in Na⁺/H⁺ antiporters Landreh, M, Gupta, K, Benesch, JL, Degiacomi, MT, Liko, I, Robinson, CV, Marklund, EG, Drew, D, Gault, J, Coinçon, M, Uzdavinys, P	Nat Commun	2017
8383669	Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli Padan, E, Taglicht, D, Schuldiner, S	J. Biol. Chem.	1993
18000046	A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension Muend, S, Xiang, M, Rao, R, Feng, M	Proc. Natl. Acad. Sci. U.S.A.	2007
18508966	Characterization of the sodium/hydrogen exchanger NHA2 Andersson, S, Bobulescu, IA, Fuster, DG, Shi, M, Zhang, J, Moe, OW	J Am Soc Nephrol	2008