POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter

Stable Identifier
R-HSA-2972956
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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The STAT3 gene is bound by POU5F1 (OCT4) (Boyer et al. 2005, Lister et al. 2009, Jung et al. 2010), SOX2 (Boyer et al. 2005, Lister et al. 2009), and NANOG (Boyer et al. 2005, Lister et al. 2009) and POU5F1 (Babaie et al. 2007, Greber et al. 2007), SOX2 (Greber et al. 2007), and NANOG (Greber et al. 2007) activate expression.
Literature References
PubMed ID Title Journal Year
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Thomson, JA, Nery, JR, Ye, Z, Pelizzola, M, Ruotti, V, Lister, R, Antosiewicz-Bourget, J, Tonti-Filippini, J, Edsall, L, Hawkins, RD, Lee, L, Ecker, JR, Dowen, RH, Hon, G, Ren, B, Ngo, QM, Stewart, R, Millar, AH

Nature 2009
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Lehrach, H, Greber, B, Adjaye, J

BMC Dev. Biol. 2007
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Adjaye, J, Kahlem, P, Lehrach, H, Vilo, J, Peterson, H, Chavez, L, Jung, M

PLoS One 2010
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
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