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VEGFA [extracellular region]
Stable Identifier
R-HSA-2975974
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Vascular endothelial growth factor A, VEGFA_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Regulation of gene expression by Hypoxia-inducible Factor (Homo sapiens)
Expression of VEGFA (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
VEGFA gene expression is inhibited by the TFAP2A homodimer (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
VEGFs [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
AAMP gene expression is positively regulated by VEGF (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGF ligand-receptor interactions (Homo sapiens)
Homodimerization of VEGF proteins (Homo sapiens)
VEGF [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGF dimer [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGF binds to VEGFR leading to receptor dimerization (Homo sapiens)
VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Homo sapiens)
VEGFA,C,D dimers [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGFR2:VEGFA,C,D [plasma membrane] (Homo sapiens)
VEGFA,C,D dimers [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)
VEGFA,VEGFB,PGF dimers [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGFR1 dimer:VEGFA, VEGFB, PGF dimers [plasma membrane] (Homo sapiens)
VEGFA,VEGFB,PGF dimers [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11731620
New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation
Huez, I
,
Bornes, S
,
Bresson, D
,
Créancier, L
,
Prats, H
Mol Endocrinol
2001
11563986
A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon
Tee, MK
,
Jaffe, RB
Biochem J
2001
External Reference Information
External Reference
UniProt:P15692 VEGFA
Gene Names
VEGFA, VEGF
Chain
chain:1-395, chain:1-, chain:-395
Reference Genes
COSMIC (genes):VEGFA VEGFA
dbSNP Gene:7422 VEGFA
ENSEMBL:ENSG00000112715 VEGFA
Participates
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
VEGFs [extracellular region] (Homo sapiens)
VEGF [extracellular region] (Homo sapiens)
as an output of
VEGFA gene expression is inhibited by the TFAP2A homodimer (Homo sapiens)
Expression of VEGFA (Homo sapiens)
as a component of
VEGFA dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
VEGFA [platelet alpha granule lumen]
Inferred To
vegfaa [extracellular region]
(Danio rerio)
Vegfa [extracellular region]
(Mus musculus)
Vegfa [extracellular region]
(Rattus norvegicus)
vegfa [extracellular region]
(Xenopus tropicalis)
VEGFA [extracellular region]
(Bos taurus)
VEGFA [extracellular region]
(Canis familiaris)
VEGFA [extracellular region]
(Gallus gallus)
VEGFA [extracellular region]
(Sus scrofa)
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17948 FLT1
1
VEGFR1 [plasma membrane]
(R-HSA-3004464)
0.819
5
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.808
5
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.77
5
UniProt:P15692 VEGFA
2
VEGFA [platelet alpha granule lumen]
(R-HSA-3132764)
VEGFA [extracellular region]
(R-HSA-2975974)
0.719
10
UniProt:P49765 VEGFB
2
VEGFB [platelet alpha granule lumen]
(R-HSA-3132756)
VEGFB [extracellular region]
(R-HSA-2975973)
0.483
2
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