NOTCH2 stimulates GZMB transcription

Stable Identifier
R-HSA-2976551
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NOTCH2 stimulates GZMB transcription
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NOTCH2 coactivator complex together with CREB1 and EP300 stimulates transcription of GZMB (granzyme B), which is important for the cytotoxic function of CD8+ T-cells (Maekawa et al. 2008).
Literature References
PubMed ID Title Journal Year
18724371 Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity

Saito, T, Sakata-Yanagimoto, M, Kurihara, T, Sone, S, Taniuchi, I, Kojima, H, Minato, Y, Kitamura, A, Ishifune, C, Yasutomo, K, Chiba, S, Yagita, H, Maekawa, Y

Nat. Immunol. 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NOTCH2 coactivator complex:p-S133-CREB1:EP300:GZMB Gene [nucleoplasm] (Homo sapiens)
Active Unit
NOTCH2 Coactivator Complex [nucleoplasm]
EP300 [nucleoplasm]
p-S133-CREB1 [nucleoplasm]
Inferred From
Notch2 stimulates Gzmb transcription (Mus musculus)
Authored
Orlic-Milacic, M  (2013-01-11)
Reviewed
Ilagan, MXG  (2013-04-25)
Boyle, S  (2013-04-25)
Created
Orlic-Milacic, M  (2013-01-10)
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