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Btn-ACACA [cytosol]
Stable Identifier
R-HSA-2976730
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Acetyl-CoA carboxylase 1, ACACA_HUMAN, ACC1
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
ChREBP activates metabolic gene expression (Homo sapiens)
Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Homo sapiens)
ACC [cytosol] (Homo sapiens)
Btn-ACACA [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Carnitine metabolism (Homo sapiens)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)
Btn-ACACA:2Mn2+ polymer [cytosol] (Homo sapiens)
Btn-ACACA:2Mn2+ [cytosol] (Homo sapiens)
Btn-ACACA [cytosol] (Homo sapiens)
Fatty acyl-CoA biosynthesis (Homo sapiens)
acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Homo sapiens)
Btn-ACACA [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Biotin transport and metabolism (Homo sapiens)
An unknown protease degrades ACACA (Homo sapiens)
Btn-ACACA:2Mn2+ [cytosol] (Homo sapiens)
Btn-ACACA [cytosol] (Homo sapiens)
HLCS biotinylates ACACA:Mn2+ (Homo sapiens)
Btn-ACACA:2Mn2+ [cytosol] (Homo sapiens)
Btn-ACACA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13085 ACACA
Gene Names
ACACA, ACAC, ACC1, ACCA
Chain
chain:1-2346
Reference Genes
BioGPS Gene:31 ACACA
CTD Gene:31 ACACA
dbSNP Gene:31 ACACA
ENSEMBL:ENSG00000275176.4 ACACA
ENSEMBL:ENSG00000278540 ACACA
ENSEMBL:ENSG00000278540.5 ACACA
HGNC:84 ACACA
KEGG Gene (Homo sapiens):31 ACACA
Monarch:31 ACACA
NCBI Gene:31 ACACA
OMIM:200350 ACACA
UCSC:Q13085 ACACA
Reference Transcript
RefSeq:XM_017024555.1 ACACA
RefSeq:NM_198834.2 ACACA
RefSeq:NM_198836.2 ACACA
RefSeq:NM_198837.1 ACACA
RefSeq:NM_198838.1 ACACA
RefSeq:NM_198839.2 ACACA
RefSeq:XM_011524703.1 ACACA
Other Identifiers
11718264_a_at
11723307_a_at
11754514_a_at
16843728
212186_PM_at
212186_at
31
3754471
3754472
3754473
3754474
3754475
3754476
3754477
3754478
3754479
3754481
3754482
3754486
3754487
3754488
3754489
3754490
3754492
3754493
3754515
3754516
3754517
3754521
3754528
3754529
3754530
3754534
3754535
3754536
3754537
3754539
3754540
3754542
3754544
3754546
3754555
3754556
3754557
3754558
3754560
3754563
3754566
3754568
3754569
3754570
3754571
3754572
3754574
3754575
3754576
3754577
3754578
3754579
3754582
3754584
3754585
3754586
3754587
3754588
3754589
3754590
3754592
3754593
3754594
3754597
3754598
3754599
3754600
3754601
3754610
3754611
3754612
3754615
3754631
3754632
3754642
38528_at
49091_at
78783_at
8014487
A_23_P141434
A_32_P215318
A_33_P3334225
GO:0000166
GO:0001650
GO:0001894
GO:0003824
GO:0003989
GO:0005515
GO:0005524
GO:0005634
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0006084
GO:0006629
GO:0006631
GO:0006633
GO:0006790
GO:0008152
GO:0015629
GO:0016874
GO:0019538
GO:0042802
GO:0043226
GO:0044281
GO:0046872
GO:0046949
GO:0051289
GO:0055086
GO:0055088
GO:0065003
GO:0071380
GO:1901135
GO:2001295
HMNXSV003011928
Hs.7232.0.S2_3p_at
ILMN_1772123
ILMN_2331636
PH_hs_0026272
TC17001406.hg
TC17002601.hg
Participates
as a member of
ACC [cytosol] (Homo sapiens)
as a component of
Btn-ACACA:2Mn2+ [cytosol] (Homo sapiens)
Other forms of this molecule
ACACA [cytosol]
Inferred To
acaca [cytosol]
(Xenopus tropicalis)
ACC [cytosol]
(Drosophila melanogaster)
ACACA [cytosol]
(Bos taurus)
pod-2 [cytosol]
(Caenorhabditis elegans)
Btn-ACACA [cytosol]
(Canis familiaris)
Btn-ACACA [cytosol]
(Danio rerio)
Btn-ACACA [cytosol]
(Dictyostelium discoideum)
Btn-ACACA [cytosol]
(Gallus gallus)
Btn-ACACA [cytosol]
(Mus musculus)
Btn-ACACA [cytosol]
(Plasmodium falciparum)
Btn-ACACA [cytosol]
(Rattus norvegicus)
Btn-ACACA [cytosol]
(Saccharomyces cerevisiae)
Btn-ACACA [cytosol]
(Schizosaccharomyces pombe)
Btn-ACACA [cytosol]
(Sus scrofa)
Modified Residues
Name
N6-biotinyl-L-lysine at 786
Coordinate
786
PsiMod Name
N6-biotinyl-L-lysine [MOD:00126]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine.
Cross References
RefSeq
XP_016880044.1
,
NP_942135.1
,
NP_942133.1
,
NP_942131.1
,
XP_011523005.1
,
NP_942136.1
,
NP_942134.1
Guide to Pharmacology - Targets
1263
OpenTargets
ENSG00000278540
ZINC - Substances
ACACA_HUMAN
ZINC target
Q13085
PRO
Q13085
PDB
2YL2
,
6G2H
,
6G2D
,
6G2I
,
3COJ
,
4ASI
ZINC - Investigational
ACACA_HUMAN
HPA
ENSG00000278540-ACACA
GeneCards
Q13085
Ensembl
ENSP00000478547
,
ENSP00000479901
,
ENSP00000483674
,
ENST00000613687
,
ENSP00000483300
,
ENSP00000482269
,
ENST00000619487
,
ENSP00000480031
,
ENST00000616317
,
ENSP00000482368
,
ENST00000617649
,
ENST00000611803
,
ENST00000614428
,
ENST00000621312
,
ENST00000612895
,
ENSG00000275176
,
ENSP00000478577
,
ENSG00000278540
Pharos - Targets
Q13085
ZINC - Predictions - Purchasable
ACACA_HUMAN
Orphanet
28193
HMDB Protein
HMDBP00047
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9CQ20
1
Mid1ip1 [cytosol]
(R-MMU-8867328)
0.642
4
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.591
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.564
2
UniProt:Q13085 ACACA
2
Btn-ACACA [cytosol]
(R-HSA-2976730)
ACACA [cytosol]
(R-HSA-1660609)
0.558
2
UniProt:O60218 AKR1B10
1
AKR1B10 [cytosol]
(R-HSA-2855246)
0.556
4
UniProt:Q15418 RPS6KA1
7
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
0.527
2
UniProt:P25098 GRK2
4
p-S29-ADRBK1 [cytosol]
(R-HSA-9645318)
ADRBK1 [cilium]
(R-HSA-5632504)
p-S29-ADRBK1 [plasma membrane]
(R-HSA-111969)
GRK2 [plasma membrane]
(R-HSA-50270)
0.527
2
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.524
2
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