Reactome | Btn-ACACA [cytosol]

Btn-ACACA [cytosol]

Stable Identifier

R-HSA-2976730

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Acetyl-CoA carboxylase 1, ACACA_HUMAN, ACC1

Icon

Locations in the PathwayBrowser for interactor UniProt:Q15418 RPS6KA1

Expand all

External Reference Information

External Reference

UniProt:Q13085 ACACA

Gene Names

ACACA, ACAC, ACC1, ACCA

Chain

chain:1-2346

Reference Genes

BioGPS Gene:31 ACACA

CTD Gene:31 ACACA

dbSNP Gene:31 ACACA

ENSEMBL:ENSG00000278540 ACACA

HGNC:84 ACACA

KEGG:hsa:31 ACACA

Monarch:31 ACACA

NCBI Gene:31 ACACA

OMIM:200350 ACACA

UCSC:Q13085 ACACA

Reference Transcript

Participates

as a component of

Btn-ACACA:2Mn2+ [cytosol] (Homo sapiens)

Other forms of this molecule

ACACA [cytosol]

Inferred To

acaca [cytosol] (Xenopus tropicalis)

ACC [cytosol] (Drosophila melanogaster)

ACACA [cytosol] (Bos taurus)

ACACA [cytosol] (Canis familiaris)

ACACA [cytosol] (Sus scrofa)

pod-2 [cytosol] (Caenorhabditis elegans)

Btn-ACACA [cytosol] (Dictyostelium discoideum)

Btn-ACACA [cytosol] (Gallus gallus)

Btn-ACACA [cytosol] (Mus musculus)

Btn-ACACA [cytosol] (Plasmodium falciparum)

Btn-ACACA [cytosol] (Rattus norvegicus)

Btn-ACACA [cytosol] (Saccharomyces cerevisiae)

Btn-ACACA [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

N6-biotinyl-L-lysine at 786

Coordinate

786

PsiMod Name

N6-biotinyl-L-lysine [MOD:00126]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine.

Cross References

Guide to Pharmacology - Targets

1263

OpenTargets

ENSG00000278540

ENSEMBL

ENST00000613687, ENST00000617649, ENST00000616317, ENSG00000278540, ENSG00000275176, ENST00000612895, ENSP00000479901, ENSP00000478547, ENST00000611803, ENST00000614428, ENSP00000482269, ENSP00000480031, ENSP00000483674, ENSP00000483300, ENSP00000478577, ENST00000621312, ENSP00000482368, ENST00000619487

ZINC - Substances

ACACA_HUMAN

ZINC target

Q13085

PRO

Q13085

GlyGen

Q13085

PDB

6G2H, 8XL1, 2YL2, 8XL2, 8XL0, 4ASI, 3COJ, 6G2D, 6G2I, 8XKZ

ZINC - Investigational

ACACA_HUMAN

HPA

ENSG00000278540-ACACA

GeneCards

ACACA

Pharos - Targets

Q13085

ZINC - Predictions - Purchasable

ACACA_HUMAN

HMDB Protein

HMDBP00047

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9CQ20	1	Mid1ip1 [cytosol] (R-MMU-8867328)	0.642	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.591	3
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.564	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:Q13085 ACACA	2	Btn-ACACA [cytosol] (R-HSA-2976730) ACACA [cytosol] (R-HSA-1660609)	0.558	2
UniProt:O60218 AKR1B10	1	AKR1B10 [cytosol] (R-HSA-2855246)	0.556	4
UniProt:P25098 GRK2	4	GRK2 [plasma membrane] (R-HSA-50270) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [cytosol] (R-HSA-9645318)	0.527	2
UniProt:Q15418 RPS6KA1	7	p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) RPS6KA1 [cytosol] (R-HSA-444256) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860)	0.527	2
UniProt:Q9H6Z9 EGLN3	2	EGLN3 [cytosol] (R-HSA-1234115) EGLN3 [nucleoplasm] (R-HSA-1234104)	0.527	2
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.524	2
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.463	9

Cite Us!