Reactome | TSG101 [endosome membrane]

TSG101 [endosome membrane]

Stable Identifier

R-HSA-2980549

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Tumor susceptibility gene 101 protein, TS101_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99816 TSG101

Gene Names

TSG101

Chain

initiator methionine:1, chain:2-390

Reference Genes

BioGPS Gene:7251 TSG101

COSMIC (genes):TSG101 TSG101

CTD Gene:7251 TSG101

dbSNP Gene:7251 TSG101

ENSEMBL:ENSG00000074319 TSG101

ENSEMBL:ENSG00000074319.13 TSG101

HGNC:15971 TSG101

KEGG Gene (Homo sapiens):7251 TSG101

Monarch:7251 TSG101

NCBI Gene:7251 TSG101

OMIM:601387 TSG101

UCSC:Q99816 TSG101

Reference Transcript

RefSeq:NM_006292.3 TSG101

Other Identifiers

11715944_at

11753797_a_at

11753798_x_at

147_at

16736508

201758_PM_at

201758_at

3365444

3365445

3365446

3365450

3365451

3365464

3365465

3365466

3365471

3365475

3365476

3365477

3365478

3365480

3365481

7251

7947015

A_23_P75839

GE59479

GO:0000122

GO:0000813

GO:0001558

GO:0003677

GO:0003714

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005730

GO:0005737

GO:0005768

GO:0005769

GO:0005770

GO:0005771

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006858

GO:0006886

GO:0006914

GO:0007049

GO:0007175

GO:0008285

GO:0008333

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0016236

GO:0019076

GO:0023052

GO:0030154

GO:0030163

GO:0030216

GO:0031410

GO:0031625

GO:0031901

GO:0031902

GO:0036211

GO:0036258

GO:0039702

GO:0042059

GO:0042803

GO:0043130

GO:0043162

GO:0043226

GO:0043328

GO:0043405

GO:0044877

GO:0045893

GO:0046755

GO:0046790

GO:0048306

GO:0048856

GO:0051301

GO:0051726

GO:0061024

GO:0070062

GO:0090148

GO:0090543

GO:0097352

GO:0140110

GO:1903543

GO:1903551

GO:1903774

GO:1990182

GO:2000397

HMNXSV003001575

HMNXSV003013591

PH_hs_0025977

TC11001466.hg

U82130_at

g5454139_3p_at

Participates

as a component of

ESCRT-I [endosome membrane] (Homo sapiens)

Inferred To

tsg101 [endosome membrane] (Dictyostelium discoideum)

tsg101 [endosome membrane] (Xenopus tropicalis)

Ghost homologue of TSG101 [endosome membrane] (Sus scrofa)

TSG101 [endosome membrane] (Bos taurus)

TSG101 [endosome membrane] (Canis familiaris)

TSG101 [endosome membrane] (Danio rerio)

TSG101 [endosome membrane] (Drosophila melanogaster)

tsg-101 [endosome membrane] (Caenorhabditis elegans)

Tsg101 [endosome membrane] (Mus musculus)

Tsg101 [endosome membrane] (Rattus norvegicus)

UEVLD [endosome membrane] (Gallus gallus)

Cross References

RefSeq

NP_006283.1

OpenTargets

ENSG00000074319

GeneCards

Q99816

HPA

ENSG00000074319-TSG101

Ensembl

ENSG00000074319, ENST00000251968, ENSP00000251968

ZINC target

Q99816

PRO

Q99816

Pharos - Targets

Q99816

PDB

4EJE, 1KPQ, 3P9G, 7ZLX, 1M4P, 3OBS, 3OBX, 4ZNY, 6UD0, 4YC1, 1S1Q, 5VKG, 2F0R, 7NLC, 1M4Q, 3OBQ, 3P9H, 6VME, 1KPP, 3OBU, 3IV1

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.721	5
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.718	6
UniProt:Q96IF1 AJUBA	3	AJUBA [nucleoplasm] (R-HSA-5687935) p-S-AJUBA [cytosol] (R-HSA-2574841) AJUBA [cytosol] (R-HSA-2564698)	0.683	4
UniProt:Q99LI8	1	HGS [cytosol] (R-MMU-182954)	0.683	5
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.609	2
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.581	5
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:Q9Y3M2 CBY1	3	pS20-CBY1 [nucleoplasm] (R-HSA-3769356) CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:Q13464 ROCK1	6	ROCK1 [extracellular region] (R-HSA-6806527) ROCK1 [secretory granule lumen] (R-HSA-6804967) ROCK1(1114-1354) [cytosol] (R-HSA-212524) ROCK1(1-1113) [cytosol] (R-HSA-212523) Activated ROCK1 [cytosol] (R-HSA-4687777) ROCK1 [cytosol] (R-HSA-212509)	0.508	4
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.499	2