Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CHN2 [cytosol]
Stable Identifier
R-HSA-2980572
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Beta-chimaerin, CHIO_HUMAN, ARHGAP3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
CHN2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52757 CHN2
Gene Names
CHN2, ARHGAP3, BCH
Chain
chain:1-468
Reference Genes
BioGPS Gene:1124 CHN2
COSMIC (genes):CHN2 CHN2
CTD Gene:1124 CHN2
dbSNP Gene:1124 CHN2
ENSEMBL:ENSG00000106069 CHN2
HGNC:1944 CHN2
Monarch:1124 CHN2
NCBI Gene:1124 CHN2
OMIM:602857 CHN2
UCSC:P52757 CHN2
Reference Transcript
RefSeq:NM_001293075.1 CHN2
RefSeq:NM_001039936.2 CHN2
RefSeq:NM_001293078.1 CHN2
RefSeq:NM_001293071.1 CHN2
RefSeq:NM_001293073.1 CHN2
RefSeq:NM_001293076.1 CHN2
RefSeq:NM_001293077.1 CHN2
RefSeq:NM_001293079.1 CHN2
RefSeq:NM_004067.3 CHN2
RefSeq:NM_001293069.1 CHN2
RefSeq:NM_001293070.1 CHN2
RefSeq:NM_001293080.1 CHN2
Other Identifiers
1124
11721936_a_at
11721937_a_at
11745697_a_at
11748284_a_at
11751748_a_at
11753540_a_at
11753541_x_at
11753605_a_at
11753765_a_at
11753766_x_at
11757516_s_at
207486_PM_x_at
207486_x_at
211419_PM_s_at
211419_s_at
213385_PM_at
213385_at
2994836
2994837
2994838
2994846
2994847
2994848
2994849
2994871
2994886
2994888
2994889
2994890
2994899
2994902
2994903
2994904
2994905
2994907
2994908
2994909
2994910
2994911
2994948
2994949
2994950
2994951
2994952
2994953
2994954
2994960
2994961
2994962
2994963
2994965
2994966
2994967
2994968
2994969
33244_at
8132013
A_14_P100549
A_14_P108386
A_14_P131541
A_24_P277875
A_33_P3237891
A_33_P3237894
A_33_P3237899
A_33_P3287348
A_33_P3353027
GE81345
GO:0005096
GO:0005515
GO:0005829
GO:0007165
GO:0016020
GO:0043547
GO:0045202
GO:0046872
GO:0051056
GO:0098772
HMNXSV003014324
HMNXSV003022348
HMNXSV003030559
HMNXSV003053196
Hs.286055.2.S1_3p_at
ILMN_1732716
ILMN_1774110
ILMN_2292187
ILMN_2403237
PH_hs_0019403
U07223_at
g4757979_3p_a_at
p25471
Participates
as a member of
RAC1 GAPs [cytosol] (Homo sapiens)
Inferred To
Chn2 [cytosol]
(Mus musculus)
Chn2 [cytosol]
(Rattus norvegicus)
gacM [cytosol]
(Dictyostelium discoideum)
chin-1 [cytosol]
(Caenorhabditis elegans)
CHN2 [cytosol]
(Bos taurus)
CHN2 [cytosol]
(Canis familiaris)
CHN2 [cytosol]
(Gallus gallus)
CHN2 [cytosol]
(Sus scrofa)
RhoGAP5A [cytosol]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSP00000222792
,
ENST00000421775
,
ENST00000222792
,
ENST00000412711
,
ENSP00000516243
,
ENSP00000394284
,
ENSP00000486515
,
ENST00000467441
OpenTargets
ENSG00000106069
HPA
ENSG00000106069-CHN2
ZINC - Substances
CHIO_HUMAN
ZINC target
P52757
PRO
P52757
Pharos - Targets
P52757
HMDB Protein
HMDBP10959
PDB
1XA6
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.589
4
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
6
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
